Abstract
Purpose
To verify the causal effects of diabetic retinopathy (DR) on depression, anxiety and bipolar disorder (BD).
Methods
Mendelian randomization (MR) analysis was performed to identify the causal relationships between DR and depression or anxiety or BD via using DR-related GWAS data (14,584 cases and 176,010 controls), depression-related GWAS data (59,851 cases and 113,154 controls), anxiety-related GWAS data (7016 cases and 14,745 controls) and BD-related GWAS data (41,917 cases and 371,549 controls). The inverse-variance weighted (IVW) model was adopted to estimate the causal relationship. The outcome was expressed as odds ratio (OR) with 95% confidence intervals (CI).
Results
The MR analysis results presented that DR was causally associated with a significantly increased risk of BD in the European population (IVW, OR = 1.06, 95%CI [1.03, 1.08], P = 2.44 × 10−6), while DR was unable to causally influence the risk of depression (IVW, OR = 1.01, 95%CI [0.99, 1.04], P = 0.32) and anxiety (IVW, OR = 0.97, 95%CI [0.89, 1.06], P = 0.48) in the European population. Subgroup analysis based on BD identified DR causally increased the risk of bipolar I disorder (BD I) but not bipolar II disorder (BD II). Sensitivity analysis results did not show any pleiotropy and heterogeneity in both groups of analyses, indicating that the results were stable and reliable.
Conclusions
The results of the current MR analysis indicated a causal relationship between DR and BD in the European population, while there was no causal connection between DR and depression or anxiety. However, further research is needed to confirm these conclusions.
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Data availability
The data presented in this study are available in article and supplementary material.
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Acknowledgements
We sincerely thank FinnGen consortium, Ieu Open Gwas Project and Psychiatric Genomics Consortium for publicly providing all the data for this MR analysis.
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Original draft writing, CC; Data analysis, CC and YL; Idea: JH and XY; Scheme design: CC and ZW; Graphical design, CC, WY, ZW. All authors read and approved the final manuscript.
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Chengming Chen, Yanyan Lan, Zhaoyang Wang, Xiaolong Yan, and Jing Han declare no interest conflicts among them.
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Since the data adopted in this MR analysis were all publicly available data from the Finngen database, Ieu Open Gwas Project and Psychiatric Genomics Consortium, all data-related studies were approved by their respective ethical review committees and received written informed consent from patients. Therefore, this study does not need additional ethics approval.
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Chen, C., Lan, Y., Wang, Z. et al. Causal effects of diabetic retinopathy on depression, anxiety and bipolar disorder in the European population: a Mendelian randomization study. J Endocrinol Invest 47, 585–592 (2024). https://doi.org/10.1007/s40618-023-02176-3
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DOI: https://doi.org/10.1007/s40618-023-02176-3