Skip to main content
SpringerLink
Log in

Value of painless transvaginal four-dimensional hysterosalpingo contrast sonography in reducing venous intravasation: a comparative study

  • Original Paper
  • Published:
Journal of Ultrasound Aims and scope Submit manuscript

Abstract

Objective

To investigate the value of painless transvaginal four-dimensional hysterosalpingo contrast sonography (TV 4-D HyCoSy) in reducing venous intravasation and its influencing factors through a retrospective comparative study on conventional TV 4-D HyCoSy.

Materials and methods

A total of 451 patients were enrolled in this study from Jan. 2019 to Oct. 2021. There were 249 patients in the painless TV 4-D HyCoSy group and 202 patients in the conventional TV 4-D HyCoSy group. The incidence of venous intravasation and its related influencing factors were analyzed and compared between these two groups. The difficulty of image evaluation for the diagnosis was also compared.

Results

There was no significant difference in the baseline characteristics between the painless group and the conventional group (p > 0.05). Compared with the conventional group, the painless group had a lower incidence of venous intravasation (16.9 vs. 24.8%; p = 0.039). Painless TV 4-D HyCoSy was more effective in reducing venous intravasation in patients with primary infertility (p = 0.032) without a history of pelvic surgery (p = 0.008) or ectopic pregnancy (p = 0.018). Logistic regression analysis demonstrated that painless TV 4-D HyCoSy and endometrial thickness > 5 mm were protective factors for venous intravasation. Moreover, the diagnostic procedure was easier in the painless group than in the conventional group (p = 0.002).

Conclusions

Painless TV 4D-HyCoSy may be an effective mode in reducing the incidence of venous intravasation and improving the diagnosis of patency of fallopian tubes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Data availability

The data that support the finding of this study are available from the corresponding author, upon reasonable request.

References

  1. Louis JF, Thoma ME, Sørensen DN et al (2013) The prevalence of couple infertility in the United States from a male perspective: evidence from a nationally representative sample. Andrology 1(5):741–748

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. Bushnik T, Cook JL, Yuzpe AA, Tough S, Collins J (2012) Estimating the prevalence of infertility in Canada. Hum Reprod 27(3):738–746

    Article  PubMed  PubMed Central  Google Scholar 

  3. National Collaborating Centre for Ws, Children's H. National Collaborating Centre for Ws, Children's H (2004) National Institute for Health and Clinical Excellence: guidance. Fertility: assessment and treatment for people with fertility problems. National Collaborating Centre for Women’s and Children’s Health. RCOG Press

  4. Jain T (2006) Socioeconomic and racial disparities among infertility patients seeking care. Fertil Steril 85(4):876–881

    Article  PubMed  Google Scholar 

  5. He Y, Geng Q, Liu H, Han X (2013) First experience using 4-dimensional hysterosalpingo-contrast sonography with SonoVue for assessing fallopian tube patency. J Ultrasound Med 32(7):1233–1243

    Article  PubMed  Google Scholar 

  6. Chen F, Quan J, Huang P, You X (2017) Hysterosalpingo-contrast sonography with four-dimensional technique for screening fallopian tubal patency: let’s make an exploration. J Minim Invasive Gynecol 24(3):407–414

    Article  PubMed  Google Scholar 

  7. Wang W, Zhou Q et al (2018) Influence factors on contrast agent venous intravasation during transvaginal 4-dimensional hysterosalpingo-contrast sonography. J Ultrasound Med 37(10):2379–2385

    Article  PubMed  Google Scholar 

  8. He Y, Wu H, Xiong R et al (2019) Intravasation affects the diagnostic image quality of transvaginal 4-dimensional hysterosalpingo-contrast sonography with SonoVue. J Ultrasound Med 38(8):2169–2180

    Article  PubMed  CAS  Google Scholar 

  9. Shi J, Li S-S, Wu H et al (2019) The influencing factors of venous intravasation during transvaginal four-dimensional hysterosalpingo-contrast sonography with SonoVue. Ultrasound Med Biol 45(9):2273–2280

    Article  PubMed  Google Scholar 

  10. Ludwin A, Ludwin I, Martins WP (2018) Venous intravasation during evaluation of tubal patency by ultrasound contrast imaging. Ultrasound Obstet Gynecol 51(1):143–145

    Article  PubMed  CAS  Google Scholar 

  11. Saunders RD, Shwayder JM, Nakajima ST (2011) Current methods of tubal patency assessment. Fertil Steril 95(7):2171–2179

    Article  PubMed  Google Scholar 

  12. Schankath AC, Fasching N, Urech-Ruh C, Hohl MK, Kubik-Huch RA (2012) Hysterosalpingography in the workup of female infertility: indications, technique and diagnostic findings. Insights Imaging 3(5):475–483

    Article  PubMed  PubMed Central  Google Scholar 

  13. Wang W, Zhou Q, Gong Y et al (2017) Assessment of fallopian tube fimbria patency with 4-dimensional hysterosalpingo-contrast sonography in infertile women. J Ultrasound Med 36(10):2061–2069

    Article  PubMed  Google Scholar 

  14. Guo J, Wang SS, Cheng Q et al (2014) Analysis on the countercurrent of contrast medium in transvaginal real-time three-dimensional hysterosalpingo-contrast sonography. Chin J Med Imag Technol 30(7):1063–1066

    Google Scholar 

  15. Savelli L, Pollastri P, Guerrini M et al (2009) Tolerability, side effects, and complications of hysterosalpingocontrast sonography (HyCoSy). Fertil Steril 92(4):1481–1486

    Article  PubMed  Google Scholar 

  16. Wang W, Zhou Q, Zhou X, Chen Z, Zhang H (2018) Influence factors on contrast agent venous intravasation during transvaginal 4-dimensional hysterosalpingo-contrast sonography. J Ultrasound Med 37(10):2379–2385

    Article  PubMed  Google Scholar 

  17. Dusak A, Ekinci F, Görük N et al (2013) Venous intravasation as a complication and potential pitfall during hysterosalpingography: re-emerging study with a novel classification. J Clin Imaging Sci 3(1):67

    Article  PubMed  PubMed Central  Google Scholar 

  18. Bhoil R, Sood D, Sharma T et al (2016) Contrast intravasation during hysterosalpingography. Pol J Radiol 81:236–239

    Article  PubMed  PubMed Central  Google Scholar 

  19. Tur-Kaspa I, Seidman DS, Soriano D et al (1998) Hysterosalpingography with a balloon catheter versus a metal cannula: a prospective, randomized, blinded comparative study. Hum Reprod 13(1):75–77

    Article  PubMed  CAS  Google Scholar 

  20. de Agostini A (2006) An unexpected role for anticoagulant heparan sulfate proteoglycans in reproduction. Swiss Med Wkly 136(37–38):583–590

    PubMed  Google Scholar 

  21. McDonough PG (2004) Grading a developmental continuum–elegy on the rise and fall of the endometrial biopsy. Fertil Steril 82(5):1286–1292

    Article  PubMed  Google Scholar 

  22. Nor HM, Jayapragasam K, Abdullah B (2009) Diagnostic image quality of hysterosalpingography: ionic versus non ionic water soluble iodinated contrast media. Biomed Imaging Interv J 5(3):e29

    Google Scholar 

Download references

Funding

This study was funded by National Natural Science Foundation of China (NO. 82272011). Natural Science Foundation of Guangdong Province (NO. 2022A1515012155). Shenzhen Futian District health public welfare program (NO. FTWS2021043, FTWS2021078, FTWS2021041). 2023 Guangdong Provincial Health Appropriate Technology Promotion Project (NO. 159).

Author information

Author notes

  1. Mengjie Chen and Shiying Huang are co-first authors.

Authors and Affiliations

  1. Department of Medical Ultrasonics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518033, China

    Mengjie Chen, Shiying Huang, Changlin Song, Xiaomin Chen, Jiajia Chen, Guojuan Bu, Huiying Zhang, Wanling Huang, Juan Fu & Erjiao Xu

Authors
  1. Mengjie Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shiying Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Changlin Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xiaomin Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jiajia Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Guojuan Bu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Huiying Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Wanling Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Juan Fu
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Erjiao Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors contributed to the study conception and design. MC: project proposal/manuscript writing/data collection/statistical analysis; SH: manuscript writing/data collection/statistical analysis; EX: project development/manuscript editing; JF: project proposal/data collection; Other authors: data collection. The first draft of the manuscript was written by MC and SH, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Juan Fu or Erjiao Xu.

Ethics declarations

Conflict of interest

The authors report no competing financial interests nor conflicts of interest.

Ethics approval

This study was approved by the the Ethics Committee of The Eighth Affiliated Hospital of Sun Yat-sen University (2022-057-02).

Consent for publication

All authors gave consent for publication.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOC 51 KB)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, M., Huang, S., Song, C. et al. Value of painless transvaginal four-dimensional hysterosalpingo contrast sonography in reducing venous intravasation: a comparative study. J Ultrasound (2024). https://doi.org/10.1007/s40477-023-00847-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s40477-023-00847-8

Keywords

Search

Navigation