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An unusual onset of pediatric acute lymphoblastic leukemia

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Abstract

Acute lymphoblastic leukemia is the most frequent cancer in children: it represents 80% of leukemias and about 24% of all neoplasms diagnosed between 0 and 14 years. Acute lymphoblastic leukemia mainly affects children between 2 and 5 years old and in this age group the incidence is about 80–90 cases per million per year. In acute lymphoblastic leukemia, cancer cells multiply rapidly and accumulate in the bone marrow and subsequently invade the blood. However, at the time of diagnosis, leukemia rarely occurs outside the bone marrow or blood vessels and the extramedullary involvement happens mostly in patients with refractory or relapsing disease. In this article, we report an unusual clinical presentation of acute B cell lymphoblastic leukemia with intestinal and ovarian localizations in a 5-year-old girl.

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Authors and Affiliations

  1. Unit of Radiology and Ultrasound, A.O.R.N. Santobono-Pausilipon, Pausilipon Hospital, Naples, Italy

    Carmela Brillantino & Eugenio Rossi

  2. Unit of Pathological Anatomy, A.O.R.N. Santobono-Pausilipon, Pausilipon Hospital, Naples, Italy

    Delfina Bifano

  3. Department Life and Health “V. Tiberio”, University of Molise, Francesco De Sanctis st 1, 86100, Campobasso, Italy

    Rocco Minelli & Gianfranco Vallone

  4. Unit of Imaging Diagnostics, A.O.R.N. dei Colli, Cotugno Hospital, Naples, Italy

    Elio Bignardi

  5. Luigi Vanvitelli University, Naples, Italy

    Raffaele Zeccolini

  6. Unit of Radiology, A.O.R.N. Santobono-Pausilipon, Santobono Hospital, Naples, Italy

    Sonia Tamasi, Rosanna Mamone & Massimo Zeccolini

Authors
  1. Carmela Brillantino
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  2. Eugenio Rossi
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  3. Delfina Bifano
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  4. Rocco Minelli
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  5. Sonia Tamasi
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  6. Rosanna Mamone
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  7. Elio Bignardi
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  8. Raffaele Zeccolini
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  9. Massimo Zeccolini
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  10. Gianfranco Vallone
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Corresponding author

Correspondence to Rocco Minelli.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975 and its late amendments. Additional informed consented was obtained from all patients for which identifying information is not included in this article.

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Brillantino, C., Rossi, E., Bifano, D. et al. An unusual onset of pediatric acute lymphoblastic leukemia. J Ultrasound 24, 555–560 (2021). https://doi.org/10.1007/s40477-020-00461-y

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  • DOI: https://doi.org/10.1007/s40477-020-00461-y

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