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Design, synthesis and evaluation of 6-oxo-1, 6-dihydropyrimidine-2,5-dicarboxamide derivatives as MMP 13 inhibitors

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Abstract

We designed and synthsized a series of novel 6-oxo-1,6-dihydropyrimidine-2,5-dicarboxamide derivatives and evaluated their inhibition effects on MMP 3, MMP 12 and MMP 13. The pharmacological results show that they have potent and highly selective activity of inhibiting MMP 13.

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Authors and Affiliations

  1. College of Pharmacy, Jilin University, Changchun, 130021, P. R. China

    Hai-bin Lu, Shi-han Wang, Qing-min Li & Yong-sheng Wang

  2. Changchun University of Chinese Medicine, Changchun, 130021, P. R. China

    Yong-sheng Wang

Authors
  1. Hai-bin Lu
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  2. Shi-han Wang
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  3. Qing-min Li
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  4. Yong-sheng Wang
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Corresponding author

Correspondence to Yong-sheng Wang.

Additional information

Supported by the Innovative Projects of Young Teacher of Jilin University, China(No.450060441137).

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Lu, Hb., Wang, Sh., Li, Qm. et al. Design, synthesis and evaluation of 6-oxo-1, 6-dihydropyrimidine-2,5-dicarboxamide derivatives as MMP 13 inhibitors. Chem. Res. Chin. Univ. 29, 67–70 (2013). https://doi.org/10.1007/s40242-012-2131-2

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  • DOI: https://doi.org/10.1007/s40242-012-2131-2

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