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Association of serum omentin levels with microvascular complications of type 2 diabetes mellitus: a systematic review and meta-analysis

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Abstract

Background and aims

Type 2 diabetes mellitus (T2DM) is a chronic condition associated with various microvascular complications, including neuropathy, retinopathy, and nephropathy. Recent studies have suggested a potential association between serum omentin levels and the risk of developing microvascular complications in patients with T2DM. However, the existing evidence remains inconclusive. Therefore, we conducted a systematic review and meta-analysis to examine the association between serum omentin levels and microvascular complications in T2DM patients.

Methods

A comprehensive search was conducted in PubMed, Scopus, and Google Scholar databases to retrieve relevant articles published up to May 2023. Observational studies investigating omentin levels association with microvascular complications in T2DM patients were included. Data was extracted and hence analyzed.

Results

A total of seven cross-sectional articles met the inclusion criteria, with a total population of 1587 participants. The meta-analysis revealed a significant association between serum omentin levels and microvascular complications in patients with T2DM. Serum omentin levels were lower in patients with microvascular complications than in those without complications (Mean difference, 95% confidence interval: -1.31 [-2.50, -0.13], I2 = 99.62%).

Conclusion

This systematic review and meta-analysis provides evidence supporting an association between serum omentin levels and microvascular complications in patients with T2DM. The findings suggest that Omentin may be lower in T2DM patients with microvascular complications. Further research is warranted to elucidate the underlying mechanisms and explore the clinical implications of these findings.

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Acknowledgements

The authors would like to thank the researchers whose work was included in this study.

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Author notes

  1. Maedeh Bayani and Reza Khademi contributed equally to this work.

Authors and Affiliations

  1. Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Kimia Kazemzadeh & Melika Arab Bafrani

  2. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Maedeh Bayani, Mahsa Shirani, Mahsa Rezaee, Arshia Shafiei, Alireza Joudaki & Niloofar Deravi

  3. School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Reza Khademi

  4. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Seyedeh-Fatemeh Sadat-Madani

  5. School of Medicine, Fasa University of Medical Sciences, Fasa, Iran

    Adrina Habibzadeh

  6. USERN Office, Fasa University of Medical Sciences, Fasa, Iran

    Adrina Habibzadeh

  7. School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Hani Ghadri

  8. School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Mohammad Abbasalizadeh

  9. School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran

    Erfan Izadi

  10. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Hassan Asadigandomani

  11. Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran

    Seyed Mohmmadmahdi Meybodi

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  1. Kimia Kazemzadeh
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Kazemzadeh, K., Bayani, M., Khademi, R. et al. Association of serum omentin levels with microvascular complications of type 2 diabetes mellitus: a systematic review and meta-analysis. J Diabetes Metab Disord (2023). https://doi.org/10.1007/s40200-023-01359-2

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