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A self-healable and bioadhesive acacia gum polysaccharide-based injectable hydrogel for wound healing acceleration

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Abstract

The present study aimed at developing an injectable hydrogel based on acacia gum (AG) for wound healing acceleration. The hydrogels were synthetized through metal-ligand coordination mediated by Fe3+ and characterized in terms of gelation time, gel content, initial water content, swelling capacity, water retention ratio, and porosity. Moreover, FTIR, XRD and TGA analyses were performed for the hydrogels and allantoin (Alla) loaded ones. Furthermore, bioadhessiveness, and self-healing as well as antibacterial, toxicity and wound healing potentials of the hydrogels were evaluated. The hydrogels displayed fast gelation time, high swelling, porosity, and bioadhessiveness, as well as antioxidant, self-healing, antibacterial, blood clotting, and injectability properties. FTIR, XRD and TGA analyses confirmed hydrogel synthesis and drug loading. The Alla-loaded hydrogels accelerated wound healing by decreasing the inflammation and increasing the cell proliferation as well as collagen deposition. Hemocompatibility, cell cytotoxicity, and in vivo toxicity experiments were indicative of a high biocompatibility level for the hydrogels. Given the advantages of fast gelation, injectability and beneficial biological properties, the use of Alla-loaded hydrogels could be considered a new remedy for efficient wound healing.

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Acknowledgements

The authors would like to thank Dr. Ahmad Salimi, Ardabil University of Medical Sciences, for helpful suggestions with regard to the technical issues examined in the present study. The authors also would like to thank Ardabil University of Medical Sciences for its financial support (ethical code: IR.ARUM.REC.1400.016). The authors are also grateful to the staff of Iran Science Elites Federation.

Funding

The financial resources of this work were provided by Ardabil University of Medical Sciences, Ardabil, Iran.

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Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran

    Zainab Ahmadian, Mahsa Zibanejad Jelodar, Sajjad Sefareshi & Hossein Ali Ebrahimi

  2. Department of Pharmaceutics, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran

    Zainab Ahmadian

  3. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

    Marzieh Rashidipour

  4. Environmental Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

    Marzieh Rashidipour

  5. Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, 5618985991, Iran

    Masoumeh Dadkhah

  6. Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran

    Vahed Adhami

  7. Department of Medicinal Chemistry, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran

    Motaleb Ghasemian

  8. Institut für Chemieund Biochemie, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany

    Mohsen Adeli

  9. Department of Chemistry, Sharif University of Technology, Tehran, Iran

    Mohsen Adeli

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  1. Zainab Ahmadian
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Contributions

Conceptualization: Zainab Ahmadian, Mohsen Adeli; Methodology: Zainab Ahmadian, Mahsa Zibanejad Jelodar, Sajjad Sefareshi, Vahed Adhami; Formal analysis and investigation: Zainab Ahmadian, Hossein Ali Ebrahimi, Motaleb Ghasemian; Writing-original and editing: Zainab Ahmadian, Marzieh Rashidipour.

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Ahmadian, Z., Jelodar, M.Z., Rashidipour, M. et al. A self-healable and bioadhesive acacia gum polysaccharide-based injectable hydrogel for wound healing acceleration. DARU J Pharm Sci 31, 205–219 (2023). https://doi.org/10.1007/s40199-023-00475-x

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