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Comparative Study of 3D-Printed Porous Titanium Alloy with Rod Designs of Three Different Geometric Structures for Orthopaedic Implantation

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Acta Metallurgica Sinica (English Letters) Aims and scope

Abstract

Porous titanium alloy is currently widely used in clinical treatment of orthopaedic diseases for its lower elastic modulus and ability to integrate with bone tissue. At the micro-level, cells can respond to different geometries, and at the macro-level, the geometric design of implants will also affect the biological function of cells. In this study, three kinds of porous scaffolds with square, triangular and circle rod shapes were designed and 3D printed. This study observed the proliferation and differentiation of MC3T3-E1 cells during surface culture of the three types of scaffolds. It also evaluated the characteristics of the three scaffolds by means of compression tests and scanning electron microscopy to provide a reference for the design of porous titanium alloy implants for clinical applications. The trends of cell proliferation and gene expression between the three types of scaffolds were observed after treatment with two inhibitors. The results show that the square rod porous scaffolds have the best proliferative and osteogenic activities, and these findings may be due to differences in piezo-type mechanosensitive ion channel component 1 (Piezo1) and Yes-associated protein (YAP) expression caused by the macro-geometric topography.

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Acknowledgements

This study was carried out at the 3D Printing Innovation Research Centre of the Ninth People's Hospital Affiliated to the School of Medicine of Shanghai Jiao Tong University, and the authors thank the founding support from the Shanghai Municipal Key Clinical Specialty–Biomedical Materials (shslczdzk06701), the 3-year Action Plan of Shen kang Development Centre (SHDC2020CR2019B), the Huangpu District Industrial Support Fund (XK2020009), the Shanghai Engineering Research Centre of Innovative Orthopedic Instruments and Personalized Medicine (19DZ2250200) and the Industry Standard Study on 3D Printing Personalized Titanium Alloy Pelvic Reconstruction Prosthesis (21DZ2201500).

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  1. Jiaxin Li and Haozhang Zhong have contributed equally to this work.

Authors and Affiliations

  1. Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, China

    Jiaxin Li & Jinglong Yan

  2. Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China

    Jiaxin Li, Bojun Cao, Zhaoyang Ran, Jia Tan, Liang Deng & Yongqiang Hao

  3. Institute of Materials Modification and Modeling, Shanghai Jiao Tong University, Shanghai, 200240, China

    Haozhang Zhong

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  1. Jiaxin Li
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Li, J., Zhong, H., Cao, B. et al. Comparative Study of 3D-Printed Porous Titanium Alloy with Rod Designs of Three Different Geometric Structures for Orthopaedic Implantation. Acta Metall. Sin. (Engl. Lett.) 37, 54–66 (2024). https://doi.org/10.1007/s40195-023-01573-0

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