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When the Path to Parenthood Does Not Go as Planned: Genetic Counseling for Infertility and Miscarriage

  • Counseling and Testing (C Walton and C Reiser, Section Editors)
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Abstract

Purpose of Review

The understanding of genetic contributions to miscarriage and infertility have benefited from advancements in genetic technologies, such as chromosomal microarray and next generation sequencing. Even with these modern tools, there continue to be disparities in management and counseling. This review explores recent genetic advances in reproductive health and provides evidence that genetic counseling by a genetic counselor empowers individuals to make appropriate reproductive decisions based upon their experience and values.

Recent Findings

The standard of care for products of conception testing is now chromosomal microarray. Genetic testing should be considered in cases of low sperm count, premature ovarian failure, and in context of family history. Expanded reproductive options, including preimplantation genetic testing, may increase the chances of live birth in cases of recurrent miscarriage, age-related infertility, and previous failed IVF cycles.

Summary

Modern genetic tools may delineate underlying causes of infertility or miscarriage. In addition to processing the complex emotions related to infertility and miscarriage, patients also value understanding the genetic contributions when making informed decisions about reproductive health.

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Authors and Affiliations

  1. Sanford Health, 1500 W 22nd St STE 102, Sioux Falls, SD, 57105, USA

    Jason D. Flanagan & RaeAnn L. Kragenbring

  2. Sanford Health, 801 Broadway N Fargo, Fargo, ND, 58122, USA

    Ellen A. Johnson & Heidi R. Albers

  3. Sanford Health, 1233 34th St., 56601, Bemidji, Minnesota, USA

    Jennifer R. Leonhard

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  1. Jason D. Flanagan
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Correspondence to Jason D. Flanagan.

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Flanagan, J.D., Johnson, E.A., Kragenbring, R.L. et al. When the Path to Parenthood Does Not Go as Planned: Genetic Counseling for Infertility and Miscarriage. Curr Genet Med Rep 8, 101–108 (2020). https://doi.org/10.1007/s40142-020-00189-5

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  • DOI: https://doi.org/10.1007/s40142-020-00189-5

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