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Emerging Anticancer Metabolite, Carvacrol, and its Action Mechanism

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Proceedings of the National Academy of Sciences, India Section B: Biological Sciences Aims and scope Submit manuscript

Abstract

Across the world, cancer is a major health problem in the population, causing ten million deaths a year in most countries. Studies on a promising group of natural compounds and their derivatives to devise effective treatments for various types of cancers are in progress and gaining popularity among researchers. Carvacrol is a phenolic compound with substituents of methyl and isopropyl with diverse pharmacological potential synthesized in the cytosol of the plants of the Labiatae family via a mevalonic acid pathway, carvacrol. This review article is aiming to interpret and analyze the chemistry, toxicity, and anticancer property of carvacrol along with its action mechanism. Recent studies on carvacrol using in vitro and in vivo models revealed the potential of carvacrol as an emerging anticancer compound. The present review examines the potential of carvacrol to treat cancer in a dose-dependent manner with respect to its metabolic interventions.

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Acknowledgements

Authors are thankful to the management of Lovely Professional University for providing the support to carry out the present study.

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Authors and Affiliations

  1. School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, India

    Anu Bansal & Neeta Raj Sharma

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  1. Anu Bansal
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  2. Neeta Raj Sharma
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AB contributed to template designing followed by drafting of this article. NRS was involved in conception of idea of this article and editing of the paper.

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Correspondence to Neeta Raj Sharma.

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All authors have no conflict of (competing) interests.

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Significance Statement: Carvacrol is one of the active nutraceuticals used to enhance the taste of most food, especially Italian foods. This review highlights the detailed molecular and biochemical action mechanism of carvacrol as an emergent anticancer agent.

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Bansal, A., Sharma, N.R. Emerging Anticancer Metabolite, Carvacrol, and its Action Mechanism. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. (2024). https://doi.org/10.1007/s40011-023-01531-x

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  • DOI: https://doi.org/10.1007/s40011-023-01531-x

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