Literatur
https://tinyurl.com/Krebs-in-Deutschland-2015-2016, abgerufen am 16. April 2021
Rahib L et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 2014;74(11):2913-21
Quante AS et al. Projections of cancer incidence and cancer-related deaths in Germany by 2020 and 2030.Cancer Med. 2016;5(9):2649-56
Oettle H et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA. 2007;297(3):267-77
Neoptolemos JP et al. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA. 2010;304(10):1073-81
Uesaka K et al. Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01). Lancet. 2016;388(10041):248-57
Oettle H et al. Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial. JAMA. 2013;310(14):1473-81
Neoptolemos JP et al. Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open- label, randomised, phase 3 trial. Lancet. 2017;389(10073):1011-24
Conroy T et al. FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer. N Engl J Med. 2018;379(25):2395-406
Tempero MA et al. APACT: Phase III, multicenter, international, open-label, randomized trial of adjuvant nab-paclitaxel plus gemcitabine vs gemcitabine for surgically resected pancreatic adenocarcinoma. J Clin Oncol. 2019;37(15_suppl):4000
Philip PA et al. Nab-paclitaxel plus gemcitabine in patients with locally advanced pancreatic cancer (LAPACT): a multicentre, open-label phase 2 study. Lancet Gastroenterol Hepatol. 2020;5(3):285-94
Perri G et al. Response and survival associated with first-line FOLFIRINOX vs gemcitabine and nab-Paclitaxel chemotherapy for localized pancreatic ductal adenocarcinoma. JAMA Surg. 2020;155(9):832-9
Suker M et al. FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta- analysis. Lancet Oncol. 2016;17(6):801-10
Sohal DP et al. Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2016;34(23):2784-96
Burris HA et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15(6):2403-13
Conroy TF et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364(19):1817-25
Von Hoff DD et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 2013;369(18):1691-703
Moore MJ et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25(15):1960-6
Von Hoff DD et al. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: A Phase I/II Trial. J Clin Oncol. 2011;29(34):4548-54
Goldstein D et al. nab-Paclitaxel plus gemcitabine for metastatic pancreatic cancer: long-term survival from a phase III trial. J Natl Cancer Inst. 2015;107(2):dju413
Cunningham D et al. Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. J Clin Oncol. 2009;27(33):5513-8
Herrmann R et al. Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group. J Clin Oncol. 2007;25(16):2212-7
O'Reilly EM et al. Randomized, multicenter, phase II trial of gemcitabine and cisplatin with or without veliparib in patients with pancreas adenocarcinoma and a germline BRCA/PALB2 mutation. J Clin Oncol. 2020;38(13):1378-88
Lowery MA et al. An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions. Oncologist. 2011;16(10):1397-402
Golan et al. Maintenance olaparib for germline BRCA-mutated metastatic pancreatic cancer. N Engl J Med. 2019;381(4):317-27
Golan T et al. Overall survival from the phase 3 POLO trial: Maintenance olaparib for germline BRCA-mutated metastatic pancreatic cancer J Clin Oncol. 2021;39(3_suppl):Abstr 378
https://www.leitlinienprogramm-onkologie.de/leitlinien/pankreaskarzinom, abgerufen am 16 April. 2021
Marabelle A et al. Efficacy of pembrolizumab in patients with noncolorectal high microsatellite instability/mismatch repair-deficient cancer: results from the phase II KEYNOTE-158 study. J Clin Oncol. 2020;38(1):1-10
Wang-Gillam A et al. Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial. Lancet. 2016;387(10018):545-57
Pelzer UI et al. Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer: a phase III-study from the German CONKO-study group. Eur J Cancer. 2011;47(11):1676-81
Oettle H et al. Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer: outcomes from the CONKO-003 trial. J Clin Oncol. 2014;32(23):2423-9
Gill S et al. PANCREOX: A randomized phase III study of fluorouracil/leucovorin with or without oxaliplatin for second-line advanced pancreatic cancer in patients who have received gemcitabine-based chemotherapy. J Clin Oncol. 2016;34(32):3914-20
Sohal DPS et al. Metastatic pancreatic cancer: ASCO clinical practice guideline update. J Clin Oncol. 2018;36(24):2545-56
https://www.onkopedia.com/de/onkopedia/guidelines/pankreaskarzinom/@@guideline/html/index.html, abgerufen am 20. April 2021
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Die Autoren erklären, dass sie sich bei der Erstellung des Beitrags von keinen wirtschaftlichen Interessen haben leiten lassen. Die Autoren legen folgende potenzielle Interessenkonflikte offen: V. Heinemann: Honoraria (ich selbst: Merck, Amgen, Roche, Sanofi, Sirtex, Servier, Pfizer, Pierre-Fabre, Astra-Zeneca); Consulting oder Advisory Board (ich selbst: Merck, Amgen, Roche, Sanofi, Sirtex, BMS, MSD, Novartis, Boehringer Ingelheim, Servier, Pierre-Fabre, Celgene, Terumo); Forschungsförderung (mein Institut: Merck, Amgen, Roche, Sanofi, Boehringer Ingelheim, Sirtex, Servier); Reisemittel (Merck, Roche, Amgen, Sirtex, Bayer, Servier); C. B. Westphalen: Beratungstätigkeit/Honorare: Chugai, Bayer, Celgene, GSK, MSD, Merck, Ipsen, Roche, Servier, SIRTeX, Taiho BMS, Celgene, Shire/Baxalta, Rafael Pharmaceuticals, RedHill, Roche; Stefan Böck: Beratungs- bzw. Gutachtertätigkeit: Servier, Incyte, Fresenius, AstraZeneca. Honorare für wissenschaftliche Vorträge: Celgene, Servier
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Heinemann, V., Westphalen, C. & Böck, S. Systemische Therapie des duktalen Pankreaskarzinoms. InFo Hämatol Onkol 24, 37–47 (2021). https://doi.org/10.1007/s15004-021-8653-3
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DOI: https://doi.org/10.1007/s15004-021-8653-3