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Comparison of non-invasive imaging modalities in presurgical evaluation of temporal lobe epilepsy patients: a multicenter study

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Abstract

Intractable drug-resistant magnetic resonance imaging (MRI) negative epilepsy in one of the complicated issues in neurology. Epilepsy surgery is beneficial treatment of intractable seizures, but precise localization of epileptogenic zone is a major concern. Thirty-four MRI negative drug-resistant epilepsy patients underwent video electroencephalography (EEG), positron emission tomography (PET) scan, and voxel-based morphometry (VBM) MRI from 2014 to 2019. Then, the findings of PET scan and VBM were compared with semiology and long-term electrophysiology. Cohen’s kappa-coefficient (k) test was utilized to measure the agreement between our modalities. Among 34 patients with age ranging from 8 to 49 (mean: 29.00 ± standard deviation: 10.35), 19 were male (55.9%) and 15 were female (44.1%). Twenty-one patients (61.76%) had right temporal, 12 patients (35.3%) had left and one patient had bilateral temporal ictal focus according to video EEG. Inter-rater agreement analysis showed that the kappa index between video EEG and PET scan was of almost acceptable (more than 0.4) and there was poor agreement between video EEG and VBM (kappa index = 0.099). PET is highly concordant with video EEG in temporal lobe epilepsy (TLE) and has a considerable agreement in localizing epileptogenic zone while VBM is less.

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Data is not published but it is available from the corresponding author.

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Funding

This research study is not sponsored by any organization.

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Authors and Affiliations

  1. Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    Jafar Mehvari Habibabadi

  2. Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Abtin Doroudinia & Abbas Yousefi Koma

  3. Comprehensive Epilepsy Program, Epilepsy Monitoring Unit, Pars Hospital, Tehran, Iran

    Sayed Sohrab Hashemi Fesharaki & Sobhan Aarabi

Authors
  1. Jafar Mehvari Habibabadi
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  2. Abtin Doroudinia
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  3. Abbas Yousefi Koma
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  4. Sayed Sohrab Hashemi Fesharaki
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  5. Sobhan Aarabi
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Correspondence to Sobhan Aarabi.

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The authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest in the subject and material discussed in this manuscript.

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The informed consent of all participants for using their information was obtained under the supervision of the Ethics Committee of Shahid Beheshti University of Medical Sciences. They were also ensured about the confidentiality of their information.

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Habibabadi, J.M., Doroudinia, A., Koma, A.Y. et al. Comparison of non-invasive imaging modalities in presurgical evaluation of temporal lobe epilepsy patients: a multicenter study. Acta Neurol Belg 121, 1815–1821 (2021). https://doi.org/10.1007/s13760-020-01550-9

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  • DOI: https://doi.org/10.1007/s13760-020-01550-9

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