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Recent trends in Grubbs catalysis toward the synthesis of natural products: a review

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Abstract

A number of natural and biologically active compounds can be synthesized via ruthenium catalysis. As ruthenium is the cheapest noble metal and can be extensively used to synthesize a variety of catalysts, particular attention has been made in the synthesis of chemotherapeutic agents, polymers, biopolymers and agrochemicals through this catalysis. Ruthenium-based catalysts are well famous because of their broad range of functional group, air and moisture tolerance. Different organic reactions such as alkylation, arylation, isomerization and olefin metathesis are efficiently carried out in the presence of these catalysts within short reaction time. In 1992, Robert H. Grubbs first time introduced ruthenium-based catalyst, known as Grubbs first-generation catalyst (G-1) to carry out olefin metathesis effectively. Later on, Grubbs second-generation G-2, third-generation catalyst G-3 and Hoveyda–Grubbs catalysts such as HG-1 and HG-2 were also obtained by changing different ligands with ruthenium. In this review, recent advances in the synthesis of ruthenium-based Grubbs catalysts and their usage in natural product synthesis via olefin metathesis are discussed briefly.

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The authors are thankful to GC University, Faisalabad, for providing the facilities to carry out this work.

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  1. Department of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan

    Tahira Bano, Ameer Fawad Zahoor, Nasir Rasool & Asim Mansha

  2. Department of Pharmaceutics, Government College University Faisalabad, Faisalabad, 38000, Pakistan

    Muhammad Irfan

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Bano, T., Zahoor, A.F., Rasool, N. et al. Recent trends in Grubbs catalysis toward the synthesis of natural products: a review. J IRAN CHEM SOC 19, 2131–2170 (2022). https://doi.org/10.1007/s13738-021-02463-x

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