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Organotin (IV) complexes derived from Schiff base 1,3-bis[(1E)-1-(2-hydroxyphenyl)ethylidene] thiourea: synthesis, spectral investigation and biological study to molecular docking

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Abstract

A novel Schiff base-derived organotin (IV) complexes have been synthesized by reacting 1, 3-bis [(1E)-1-(2-hydroxyphenyl) ethylidene]thiourea (which in turn obtained by condensing thiourea with ortho-hydroxyacetophenone) with diorganotin chlorides in methanol under stirring conditions. The synthesized compounds have been characterized by elemental analysis, FT-IR, NMR (1H, 13C, 119Sn), and Mass spectrometry. The results of the spectral study revealed that the ligand act as a tri-dentate in the complexes. Biological screenings demonstrate that the complexes possess significant activity against various bacterial and fungal strains while molecular docking has shown an intercalative mode of binding. The anti-angiogenic property was evaluated using CAM assay.

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The authors are thankful to Maharishi Markandeshwar trust-Ambala Haryana-India for laboratory support.

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Authors and Affiliations

  1. Department of Chemistry, Maharishi Markandeshwar University, Sadopur, Ambala, 134007, India

    Zahoor Abbas & Manoj Kumar

  2. Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, 133207, India

    Hardeep Singh Tuli

  3. Department of Molecular Biology and Genetics, Faculty of Science, Mugla Sitki Kocman University, Kotekli Campus, TR48000, Mugla, Turkey

    Mehmet VAROL

  4. Department of Chemistry, Dyal Singh College, Karnal, India

    Shashi Sharma

  5. Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, 133207, India

    Harish Kumar Sharma

  6. Department of Chemistry, Pt. CLS. Government College, Karnal, Haryana, 132001, India

    Pallvi Aggarwal

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Abbas, Z., Tuli, H.S., VAROL, M. et al. Organotin (IV) complexes derived from Schiff base 1,3-bis[(1E)-1-(2-hydroxyphenyl)ethylidene] thiourea: synthesis, spectral investigation and biological study to molecular docking. J IRAN CHEM SOC 19, 1923–1935 (2022). https://doi.org/10.1007/s13738-021-02430-6

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  • DOI: https://doi.org/10.1007/s13738-021-02430-6

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