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Two Co(II) coordination polymers: treatment activity on non-small cell lung cancer by inducing the cancer cell apoptosis through high-intensity focused ultrasound

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Abstract

By employment of 1,4-di(1H-imidazol-1-yl)benzene (bib)) or (1,10-phenanthroline (phen) as the N-heterocyclic co-ligand, two coordination polymers of [Co(μ3-Hcpota)(phen)]n·nH2O (1) and [Co2(μ4-Hcpota)(μ3-Hcpota)(μ2-bib)2(H2O)]n (2) were produced by the solvothermal reactions between 2-(4-carboxyphenoxy)terephthalic acid (H3cpota) and Co(II) salts. In order to develop novel candidate drugs for the treatment of non-small cell lung cancer, the anticancer activities of novel compounds were assessed and the relevant mechanism of action also was discussed. Firstly, the non-small cell lung cancer cells’ viability after treated via the compounds was detected utilizing the Cell Counting Kit-8. Moreover, the apoptosis in non-small cell lung cancer cells was determined with the Western blot by measuring the Caspase-3 and Bcl-2 expression.

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Author notes

  1. Jian-Guo Sheng and Mi Tang are contributed equally to this work.

Authors and Affiliations

  1. Department of Ultrasound, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

    Jian-Guo Sheng

  2. Department of Ultrasonography, Chengdu Jinniu District Chinese Medicine Hospital, Chengdu, Sichuan, China

    Mi Tang

  3. Department of Radiology, Hainan Third People′s Hospital, Sanya, Hainan, China

    Qun Qin

  4. Department of Ultrasonography, Xuzhou Cancer Hospital of Jiangsu Province, Xuzhou, Jiangsu, China

    Da-Qiang Li

  5. Department of Ultrasonography, Yuyao Municipal People′s Hospital, Yuyao, Zhejiang, China

    Wei-Wei Chen

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  1. Jian-Guo Sheng
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  2. Mi Tang
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Correspondence to Wei-Wei Chen.

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Sheng, JG., Tang, M., Qin, Q. et al. Two Co(II) coordination polymers: treatment activity on non-small cell lung cancer by inducing the cancer cell apoptosis through high-intensity focused ultrasound. J IRAN CHEM SOC 18, 2323–2330 (2021). https://doi.org/10.1007/s13738-021-02193-0

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  • DOI: https://doi.org/10.1007/s13738-021-02193-0

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