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Denitrative functionalization of nitroarenes

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Abstract

Denitrative functionalization of nitroaromatic compounds has become a very intriguing challenge in synthetic chemistry. Herein, various methodologies for \({\text{C}}_{{sp^{2} }}\)–NO2 bond cleavage of nitroaromatic compounds have been reviewed. We survey the literature for the reactions in which nitroarenes have been used as the electrophilic coupling partners for the formation of \({\text{C}}_{{sp^{2} }}\)–O, \({\text{C}}_{{sp^{2} }}\)–S, \({\text{C}}_{{sp^{2} }}\)–N, \({\text{C}}_{{sp^{2} }}\)–H and \({\text{C}}_{{sp^{2} }}\)–C bonds via transition metal-catalyzed cross-coupling reactions. A brief discussion about the mechanism of the reactions has also been presented.

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Author notes

  1. Sajedeh Maddah-Roodan and Roghaye Soltani have contributed equally in this review.

Authors and Affiliations

  1. Department of Chemistry, College of Sciences, University of Hormozgan, 7916193145, Bandar Abbas, Iran

    Sajedeh Maddah-Roodan, Roghaye Soltani & Arash Ghaderi

  2. Department of Chemistry, Faculty of Science, University of Yazd, 89195-741, Yazd, Iran

    Sajedeh Maddah-Roodan

  3. Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, 9177948974, Mashhad, Iran

    Roghaye Soltani

Authors
  1. Sajedeh Maddah-Roodan
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  2. Roghaye Soltani
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  3. Arash Ghaderi
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Corresponding author

Correspondence to Arash Ghaderi.

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Maddah-Roodan, S., Soltani, R. & Ghaderi, A. Denitrative functionalization of nitroarenes. J IRAN CHEM SOC 18, 519–542 (2021). https://doi.org/10.1007/s13738-020-02054-2

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  • DOI: https://doi.org/10.1007/s13738-020-02054-2

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