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The multifaceted role of mangiferin in health and diseases: a review

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Abstract

A wide range of natural products including, flavonoids have been studied for their therapeutic potential in different diseases. Mangiferin (2-c-b-d-glucopyranosyl 1,3,6,7-tetrahydroxyxanthone), a natural plant xanthonoid polyphenol present mainly in the leaves and bark of Mangifera indica exhibited therapeutic activities in the treatment of various illnesses. Mounting evidence suggested mangiferin as a potent compound having diverse pharmacological activities, including antioxidant, anti-inflammatory, neuroprotective, cardioprotective, nephroprotective, hepatoprotective, anti-diabetic, anti-asthamtic, gastroprotective, immunomodulatory, anti-cancer, and hypocholesterolemic effects. Mangiferin can be considered powerful free radical scavenging activity along with multifaceted molecular targets, such as NF-ҡB, Nrf2-HO-1, PI3K/Akt, MAPK/TGF-β, SIRT-1, mTOR, AMPK, and PPARγ signaling pathways in different pathological conditions. The current review article presents an overview of major pharmacological actions and underlying pleotropic molecular mechanisms of mangiferin that have been reported in the recent literature that sheds the light on the potential of this phytoconstituent as intriguing therapeutic approach for the management of different pathological conditions. A narrative review of all the relevant papers published right from the first article on mangiferin to articles of 2020 was conducted and required data was extracted from selected papers. For the same pubmed, and other digital repository sites were explored.

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Acknowledgements

The financial support by Dr. A P J Abdul Kalam Technical University, Lucknow under Visvesvaraya Research Promotion Scheme (VRPS) is gratefully acknowledged.

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  1. Department of Pharmacology, KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad, India

    Ashok Jangra, Mandeep Kumar Arora, Anglina Kisku & Sonal Sharma

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AJ, MKA, SS, and AK equally contributed to the background research, writing, and reviewing of this manuscript.

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Correspondence to Mandeep Kumar Arora.

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Ashok Jangra has no conflict of interest. Mandeep Kumar Arora has no conflict of interest. Anglina Kisku has no conflict of interest. Sonal Sharma has no conflict of interest.

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Jangra, A., Arora, M.K., Kisku, A. et al. The multifaceted role of mangiferin in health and diseases: a review. ADV TRADIT MED (ADTM) 21, 619–643 (2021). https://doi.org/10.1007/s13596-020-00471-5

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