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Research hotspots and emerging trends in mesenchymal stem/stromal cells in bronchopulmonary dysplasia

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Abstract

Bronchopulmonary dysplasia (BPD) is a prevalent lung disease in neonates that is associated with numerous complications and high mortality. The promising approach to treat BPD is the use of mesenchymal stem cells (MSCs), However, the current treatment of MSCs presents safety concerns, including occlusion of blood vessels and tumorigenicity. In this study, relevant publications from the Web of Science Core Collection were downloaded in January 2023. The acquired data were analyzed and predicted for trends and hotspots in this field using CiteSpace software. Results revealed that in recent years, the focus of co-cited references has been primarily on the clinical studies of MSCs and the application of MSCs derivatives for treating BPD models. The keywords that have gained attention are extracellular vesicles and exosomes. The United States has emerged as the most influential co-authoring country in this field. Among the co-cited journals, the American Journal of Respiratory and Critical Care Medicine holds the highest influence. Thus, this study provides trends in publications, collaboration, research interests, and hotspots, and provides clues for novel ideas and strategies in to further MSCs treatments for BPD.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We thank Mr. Zeyan Ye for technological assistance.

Funding

This study was funded by the National Natural Science Foundation of China (Grant Nos. 82160620 to X.Z.); Natural Science Foundation of Guangxi Province (Grant Nos. 2022JJA141352 to X.Z.).

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Authors and Affiliations

  1. The School of Public Health, Guilin Medical University, 1 Zhiyuan Road, Lingui District, Guilin, 541100, People’s Republic of China

    Meng Ao, Heqian Ma, Meizhen Guo, Xuelin Dai & Xiaoying Zhang

  2. The Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Heath, 1 Zhiyuan Road, Lingui District, Guilin, 541199, People’s Republic of China

    Meng Ao, Heqian Ma, Meizhen Guo, Xuelin Dai & Xiaoying Zhang

  3. Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care, 1 Zhiyuan Road, Lingui District, Guilin, 541199, People’s Republic of China

    Meng Ao, Heqian Ma, Meizhen Guo, Xuelin Dai & Xiaoying Zhang

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Conceptualization, Investigation, Methodology, Software, Data curation, Formal analysis, Writing original draft: MA; Investigation, Methodology, Software: HM; Investigation, Methodology, Software: MG; Supervision, Validation: XD; Funding acquisition, Supervision, Writing review and editing, Project administration, Resources, Supervision: XZ.

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Publication output on MSCs research in BPD, 2006–2022 (TIF 23209 KB)

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Co-cited reference network with visualization. b–e Clustering network details with visualization of co-cited references (TIF 11622 KB)

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Co-citation network with visualization of keywords. b Keyword clustering network with visualization (TIF 14668 KB)

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Top 25 bursts of co-authorship sorted by burst strength. b Top 25 bursts of co-cited authors sorted by burst strength. c Top 25 bursts of co-cited journals sorted by burst strength. d Top 25 bursts of co-cited journals sorted by the first year of bursts (TIF 22246 KB)

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Ao, M., Ma, H., Guo, M. et al. Research hotspots and emerging trends in mesenchymal stem/stromal cells in bronchopulmonary dysplasia. Human Cell 37, 381–393 (2024). https://doi.org/10.1007/s13577-023-01018-x

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