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Exploring the future potential of mesenchymal stem/stromal cells and their derivatives to support assisted reproductive technology for female infertility applications

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Abstract

Women’s infertility impacts the quality of life of both patients and couples and has multifaceted dimensions that increase the number of challenges associated with female infertility and how to face them. Female reproductive disorders, such as premature ovarian failure (POF), endometriosis, Asherman syndrome (AS), polycystic ovary syndrome (PCOS), and preeclampsia, can stimulate infertility. In the last decade, translational medicine has advanced, and scientists are focusing on infertility therapy with innovative attitudes. Recent investigations have suggested that stem cell treatments could be safe and effective. Stem cell therapy has established a novel method for treating women’s infertility as part of a regeneration approach. The chief properties and potential of mesenchymal stem/stromal cells (MSCs) in the future of women’s infertility should be considered by researchers. Due to their high abundance, great ability to self-renew, and high differentiation capacity, as well as less ethical concerns, MSC-based therapy has been found to be an effective alternative strategy to the previous methods for treating female infertility, such as intrauterine insemination, in vitro fertilization, medicines, and surgical procedures. These types of stem cells exert their beneficial role by releasing active mediators, promoting cell homing, and contributing to immune modulation. Here we first provide an overview of MSCs and their crucial roles in both biological and immunological processes. The next large chapter covers current preclinical and clinical studies on the application of MSCs to treat various female reproductive disorders. Finally, we deliberate on the extant challenges that hinder the application of MSCs in female infertility and suggest plausible measures to alleviate these impediments.

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Authors and Affiliations

  1. Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

    Andrew Rizano

  2. Andrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

    Andrew Rizano, Ria Margiana, Supardi Supardi & Pety Narulita

  3. Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

    Andrew Rizano, Ria Margiana, Supardi Supardi & Pety Narulita

  4. Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

    Ria Margiana

  5. Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

    Ria Margiana

  6. Indonesia General Academic Hospital, Depok, Indonesia

    Ria Margiana

  7. Ciptomangunkusumo General Academic Hospital, Jakarta, Indonesia

    Ria Margiana

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AR and RM performed, wrote the manuscript, collected the references, designed the table and figures; SS modified the manuscript; PN and RM designed the manuscript and approved the final manuscript for publication. All authors read and approved the final manuscript.

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Rizano, A., Margiana, R., Supardi, S. et al. Exploring the future potential of mesenchymal stem/stromal cells and their derivatives to support assisted reproductive technology for female infertility applications. Human Cell 36, 1604–1619 (2023). https://doi.org/10.1007/s13577-023-00941-3

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