Abstract
Purpose of the study
This study aimed to investigate whether persistently high 1-h postchallenge glucose (PG) levels in a 75 g oral glucose tolerance test (75 g OGTT), as well as persistently low 1-h PG levels, are a risk factor for reclassification from normal glucose tolerance (NGT) into impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) among participants continually observed for 11 years.
Methods
This single-center retrospective study used the electronic records of all participants undergoing Ningen Dock (health checkup) at Kiryu Kosei General Hospital between 2008 and 2018. In 2008, 361 of 523 participants who received Ningen Dock had NGT. Of the 361 participants, 109 received 75 g OGTT yearly for 11 years (2008–2018), and 72 of these 109 participants showed either persistently high 1-h PG (> 155 mg/dL) or persistently low 1-h PG (< 155 mg/dL) levels. These 72 participants with NGT were analyzed to observe the 1-h PG effect on glucose tolerance alteration for 11 years. They were divided into persistently low 1-h PG (N = 50) and persistently high 1-h PG (N = 22) groups.
Results
In the low 1-h PG group, 49 participants remained to have NGT, and the remaining 1 was reclassified as having IGT. In the high 1-h PG group, 8 remained to have NGT, whereas 10 and 4 were reclassified as having IGT and T2DM, respectively.
Conclusion
High 1-h PG levels may be a risk factor for reclassification from NGT into IGT or T2DM, but not the low 1-h PG levels.
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Data availability
The datasets generated or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability
Not applicable.
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Authors and Affiliations
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KK (Kashima) collected the data. EY, TS, AO, KO (Okada), TW, KK (Kikkawa), KO (Ohshima), and SO analyzed the data. JO, MY, and SO prepared the manuscript.
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The ethics committee at Kiryu Kosei General Hospital approved our study, which conformed to the Declaration of Helsinki (as 2-K015).
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Whenever the participants received Ningen Dock, they were asked whether they agree to use their Ningen Dock’s data for future clinical study and presentation.
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The authors declare no competing interests.
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Kashima, K., Okada, J., Yamada, E. et al. Outcome of glucose tolerance condition in patients with normal glucose tolerance with either persistently high or low 1-h postchallenge glucose levels in 75 g oral glucose tolerance test. Int J Diabetes Dev Ctries 42, 652–656 (2022). https://doi.org/10.1007/s13410-021-01019-2
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DOI: https://doi.org/10.1007/s13410-021-01019-2