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Evaluation of the reciprocal interaction between hepatic steatosis and type 2 diabetes: a comparative analysis with respect to anti-diabetic treatment, glycemic control, renal and hepatic function

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Abstract

Background

This study aimed to evaluate reciprocal interaction between hepatic steatosis (HS) and type 2 diabetes (T2D) through comparative analysis of anti-diabetic treatment, glycemic control, and renal and hepatic function in T2D patients with versus without concomitant HS.

Methods

A total of 102 T2D patients were included in this cross-sectional single-center study, and patients were divided into two groups including those with HS (n = 58) and those without HS (n = 44). Data on patient demographics, current anti-diabetic treatment, and serum levels for fasting blood glucose (FBG), HbA1c (%), urea, creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lipids were recorded.

Results

Diabetic patients with HS had younger age (59.6 ± 10.5 vs. 63.5 ± 14.5 years, p = 0.034) and lower serum urea levels (28.5 (3–61) vs. 39 (14–138), p = 0.012). Metformin (74.1% in patients with HS, 65.9% in patients without HS) was the most frequent anti-diabetic treatment in both groups with similar rate of glycemic control (HbA1c < 7%, 39.7%, and 40.9% of patients, respectively). HbA1c levels were positively correlated with serum urea (r = 0.308, p = 0.042), creatinine (r = 0.306, p = 0.044), and triglyceride (r = 0.358, p = 0.017) levels only in patients without HS. In patients with HS, no significant difference was noted in ALT and AST levels with respect to anti-diabetic regimen. Logistic regression analysis revealed that the presence of proteinuria (OR, 0.327, 95% CI 0.12 to 0.91, p = 0.032) was associated with decreased likelihood of HS in T2D patients.

Conclusion

In conclusion, our findings revealed no increase in the risk of poor glycemic control, dyslipidemia, or nephropathy pertaining to concomitant HS in T2D patients, as well as no difference in ongoing anti-diabetic treatments in terms of serum ALT and AST levels.

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Availability of data and material

Raw data can be obtained upon request to the corresponding author (teslime.ayaz@erdogan.edu.tr).

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Authors and Affiliations

  1. Department of Internal Medicine, Recep Tayyip Erdogan University Faculty of Medicine, Rize, Turkey

    Teslime Ayaz, Hatice Beyazal Polat & Bilgesah Kilictas

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  1. Teslime Ayaz
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  2. Hatice Beyazal Polat
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  3. Bilgesah Kilictas
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Correspondence to Teslime Ayaz.

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Ethics approval

The study was conducted in accordance with the ethical principles stated in the “Declaration of Helsinki” and approved by the institutional ethics committee.

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Written informed consent was obtained from each patient following a detailed explanation of the objectives and protocol of the study which was conducted in accordance with the ethical principles stated in the “Declaration of Helsinki” and approved by the institutional ethics committee.

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The permission was obtained from the institutional ethics committee for the use of patient data for publication purposes.

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The authors declare no competing interests.

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Ayaz, T., Polat, H.B. & Kilictas, B. Evaluation of the reciprocal interaction between hepatic steatosis and type 2 diabetes: a comparative analysis with respect to anti-diabetic treatment, glycemic control, renal and hepatic function. Int J Diabetes Dev Ctries 42, 421–427 (2022). https://doi.org/10.1007/s13410-021-01009-4

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