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IDH2, a novel target of OGT, facilitates glucose uptake and cellular bioenergy production via NF-κB signaling to promote colorectal cancer progression

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A Correction to this article was published on 27 December 2022

This article has been updated

Abstract

Background

Although isocitrate dehydrogenase 2 (IDH2) mutations have been the hotspots in recent anticancer studies, the impact of wild-type IDH2 on cancer cell growth and metabolic alterations is still elusive.

Methods

IDH2 expression in CRC tissues was evaluated by immunohistochemistry, and the correlation between the expression level and the patient’s survival rate was analyzed. Cell functional assays included CCK8 and colony formation for cell proliferation in vitro and ectopic xenograft as in vivo experimental model for tumor progression. A targeted metabolomic procedure was performed by liquid chromatography/tandem mass spectrometry to profile the metabolites from glycolysis and tricarboxylic acid (TCA) cycle. Mitochondrial function was assessed by measuring cellular oxygen consumption (OCR) and mitochondrial membrane potential (ΔΨ). Confocal microscope analysis and Western blotting were applied to detect the expression of GLUT1 and NF-κB signaling. O-GlcNAcylation and the interaction of IDH2 with OGT were confirmed by co-immunoprecipitation, followed by Western blotting analysis.

Results

IDH2 protein was highly expressed in CRC tissues, and correlated with poor survival of CRC patients. Wild-type IDH2 promoted CRC cell growth in vitro and tumor progression in xenograft mice. Overexpression of wild-type IDH2 significantly increased glycolysis and TCA cycle metabolites, the ratios of NADH/NAD+ and ATP/ADP, OCR and mitochondrial membrane potential (ΔΨ) in CRC cells. Furthermore, α-KG activated NF-κB signaling to promote glucose uptake by upregulating GLUT1. Interesting, O-GlcNAcylation enhanced the protein half-time of IDH2 by inhibiting ubiquitin-mediated proteasome degradation. The O-GlcNAc transferase (OGT)-IDH2 axis promoted CRC progression.

Conclusion

Wild-type IDH2 reprogrammed glucose metabolism and bioenergetic production via the NF-κB signaling pathway to promote CRC development and progression. O-GlcNAcylation of IDH2 elevated the stability of IDH2 protein. And the axis of OGT-IDH2 played an essential promotive role in tumor progression, suggesting a novel potential therapeutic strategy in CRC treatment.

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Data availability

Data and material are available in Supplementary Data.

Change history

  • 17 December 2022

    The original version of this article was revised: In this article Fig. 4d was incorrect; the figure should have appeared as shown below. The original article has been corrected.

  • 27 December 2022

    A Correction to this paper has been published: https://doi.org/10.1007/s13402-022-00764-8

Abbreviations

CRC:

Colorectal cancer

PPP:

Pentose phosphate pathway

TCA:

Tricarboxylic acid cycle

GLUT1:

Glucose transporter 1

GLUT4:

Glucose transporter 4

NF-κB:

Nuclear factor kappa-B

TCA cycle:

Tricarboxylic acid cycle

OXPHOS:

Oxidative phosphorylation

OCR:

Oxygen consumption ratio

PTMs:

Post-translational modifications

IDH2:

Isocitrate dehydrogenase 2

α-KG:

Alpha-ketoglutarate

O-GlcNAc:

O-Linked β-N-acetylglucosamine

OGT:

O-GlcNAc transferase

OGA:

O-GlcNAcase

ROS:

Reactive oxygen species

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Funding

This work was supported by the National Natural Science Foundation of China (No.81471401), the Natural Science Foundation of Shaanxi Provincial of China (No.2019JZ-41) and the Opening Foundation of State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University.

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  1. Institute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, 28 Xianning West Road, Xi’an, 710049, Shaanxi, China

    Xiaoli He & Jing Wu

  2. Provincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Modern Biotechnology in Western China, Faculty of Life Science, Northwest University, 229 TaiBai North Road, Xi’an, 710069, Shaanxi, China

    Nan Wu & Yu Zhao

  3. State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Air Force Medical University, 127 Changle West Road, Xi’an, 710032, Shaanxi, China

    Renlong Li, Haohao Zhang & Yongzhan Nie

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Jing Wu and Yongzhan Nie wrote the main manuscript text. Xiaoli He and Nan Wu prepared Figs. 1–6 and Fig. 8. Renlong Li and Haohao zhang prepared the Fig. 7 and supplementary Fig S1. Yu zhao did the MASS analysis. All authors reviewed the manuscript.

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Correspondence to Yongzhan Nie or Jing Wu.

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The CRC tissue microarrays were purchased from Shanghai Outdo Biotech Co. LTD. (Shanghai, P.R.C). The mice study received approval from the institutional review board of the Air Force Medical University.

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The original version of this article was revised: In this article Fig. 4d was incorrect; the figure should have appeared as shown below. The original article has been corrected.

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He, X., Wu, N., Li, R. et al. IDH2, a novel target of OGT, facilitates glucose uptake and cellular bioenergy production via NF-κB signaling to promote colorectal cancer progression. Cell Oncol. 46, 145–164 (2023). https://doi.org/10.1007/s13402-022-00740-2

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  • DOI: https://doi.org/10.1007/s13402-022-00740-2

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