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Prepregnancy body mass index and glycated albumin in the third trimester may predict infant complications in gestational diabetes mellitus: a retrospective cohort study

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Abstract

Background

Maternal hyperglycemia, obesity, and hypertension with gestational diabetes mellitus (GDM) are risk factors for infant complications. This study aimed to investigate maternal factors and glycemic control indicators that affect infant complications in GDM.

Methods

We conducted a retrospective cohort study including 112 mothers with GDM and their infants. Multivariate logistic regression analysis was used to investigate the variables associated with good and adverse infant outcomes. We determined the cutoff values of variables that showed a significant difference in the multivariate logistic regression analysis for predicting infant complications by performing receiver operating characteristic curve analysis.

Results

In the multivariate logistic regression analysis, prepregnancy BMI and GA in the third trimester were significantly related to good and adverse infant outcomes (adjusted odds ratios [aORs], 1.62; 95% CIs 1.17–2.25, p = 0.003 and aORs, 2.77; 95% CIs 1.15–6.64, p = 0.022, respectively). The cutoff values for prepregnancy BMI and GA in the third trimester were 25.3 kg/m2 and 13.5%, respectively.

Conclusions

The importance of weight control before pregnancy and the usefulness of GA in the third trimester to predict infant complications were suggested in this study.

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Data availability

All data generated or analyzed during this study are included in this published article. The data are not publicly available due to ethical restrictions. However, the datasets are available from the corresponding author on reasonable request.

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Acknowledgements

The authors are grateful to the staff of our facility for their support. We thank American Journal Experts (AJE) for English language editing.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Saitama Medical Center Jichi Medical University, 1-847 Amanuma-Cho, Saitama, 330-8503, Japan

    Daisuke Sugawara, Eishi Makita, Misa Matsuura, Hiroaki Sato & Ko Ichihashi

  2. Department of Obstetrics and Gynecology, Saitama Medical Center Jichi Medical University, 1-847 Amanuma-Cho, Saitama, 330-8503, Japan

    Tomoyuki Kuwata

Authors
  1. Daisuke Sugawara
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  2. Eishi Makita
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  3. Misa Matsuura
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  4. Hiroaki Sato
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  5. Tomoyuki Kuwata
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  6. Ko Ichihashi
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Contributions

DS Conceptualization, Investigation, Methodology, Formal analysis, Writing-Original draft, Writing–Review & Editing. EM Investigation, Methodology, Formal analysis, Writing–Review & Editing. MM Investigation, Data curation, Formal analysis. HS Conceptualization, Methodology, Writing–Review & Editing. TK Conceptualization, Supervision, Writing–Review & Editing. KI Writing–Review & Editing, Project administration.

Corresponding author

Correspondence to Daisuke Sugawara.

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Conflict of interest

The authors declare no conflicts of interest.

Ethical standards

This study was performed in accordance with the principles of the Declaration of Helsinki and was approved by the ethics board of Saitama Medical Center Jichi Medical University (approval no. S20-070, Aug 27. 2020). An opt-out consent form was published on the website of Saitama Medical Center Jichi Medical University. This study was exempted from the requirement for written informed consent because of its retrospective design and the fact that participants chose to participate in the study by not opting out on the Saitama Medical Center Jichi Medical University webpage, which implied their tacit consent to participate in this study. None of the participants opted out of this study.

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Sugawara, D., Makita, E., Matsuura, M. et al. Prepregnancy body mass index and glycated albumin in the third trimester may predict infant complications in gestational diabetes mellitus: a retrospective cohort study. Diabetol Int 14, 280–287 (2023). https://doi.org/10.1007/s13340-023-00631-3

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  • DOI: https://doi.org/10.1007/s13340-023-00631-3

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