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Prevalence and predictors of atrial fibrillation in Japanese patients with type 2 diabetes

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Abstract

Introduction

Close association has been shown between diabetes and atrial fibrillation (AF). We conducted this single-center cross-sectional study to investigate the prevalence and predictors of AF in Japanese patients with type 2 diabetes.

Patients and methods

Patients with type 2 diabetes were eligible if 12-lead electrocardiograms were recorded at the first visit between January 2004 and December 2005. The prevalence of AF in the patients was compared with that in the Japanese general population. Multivariate logistic regression analysis was conducted to determine the effect of independent variables on the prevalence of AF and non-valvular AF.

Results

1650 patients with type 2 diabetes, 588 women and 1,059 men, with the mean age of 60 ± 13 (SD) years were studied. Among them, 72 patients had AF, accounting for 4.4%, with a sex-specific prevalence of 2.5% in women and 5.4% in men. Of the 72 patients having AF, 12 patients had valvular AF and 60 patients had nonvalvular AF. When compared with the Japanese general population, the age- and sex-adjusted risk ratio for AF was 3.47 (95% confidence interval: 2.77–4.37). The prevalence of combined nonvalvular/valvular AF and nonvalvular AF increased with age. Other relevant factors associated with AF and nonvalvular AF were male sex, presence of hypertension, and decreased platelet count.

Conclusion

Higher prevalence of AF was observed in Japanese patients with type 2 diabetes than the general population. Advanced age, male sex, and hypertension were independent predictive factors for AF.

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Change history

  • 20 May 2021

    Title of table 1 was overlapped and corrected in this version.

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Authors and Affiliations

  1. Department of Diabetology and Metabolism, Tokyo Women’s Medical University School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Sachiko Otake & Tetsuya Babazono

  2. Department of Clinical Laboratory, Tokyo Women’s Medical University School of Medicine, Tokyo, 162-8666, Japan

    Asako Sato

Authors
  1. Sachiko Otake
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  2. Asako Sato
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  3. Tetsuya Babazono
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Corresponding author

Correspondence to Asako Sato.

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Conflict of interest

SO and AS have no conflicts of interest to disclose. TB is supported through unrestricted research funding: Novartis, Eli Lilly Japan, Honoraria (e.g., lecture fees): Novo Nordisk, MSD, Takeda, Taisyo, Mitsubishi Tanabe, Chugai, Ono, Nippon Boehringer Ingelheim, Sumitomo Dainippon, Daiichi Sankyo, and Subsidies or Donations: Terumo, Teijin, Abbott, Sumitomo Dainippon, Ono, Nippon Boehringer Ingelheim, Baxter, Alcon, Chugai, Novo Nordisk, Nipro, MSD, Astellas, Mitsubishi Tanabe, Daiichi Sankyo, Taisyo, Bayer, Santen, Sanwa Kagaku.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki. Declaration of 1964 and later versions.

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Otake, S., Sato, A. & Babazono, T. Prevalence and predictors of atrial fibrillation in Japanese patients with type 2 diabetes. Diabetol Int 13, 101–107 (2022). https://doi.org/10.1007/s13340-021-00509-2

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