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miRNA regulation of G protein-coupled receptor mediated angiogenic pathways in cancer

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Abstract

Angiogenesis is an important biological process associated with plethora of physiological and patho-physiological conditions. Recent data suggests that fine balance between anti-angiogenic microRNA (miRNA) and pro-angiogenicmiRNA drive the process of neovascularization. Many of these miRNAs act via G-protein coupled receptor (GPCR) which regulates diverse physiological processes including angiogenesis. Aberrant GPCR expression and signaling through G-protein often results into uncontrolled angiogenesis, tumor development and metastasis. In this review, we discuss the new emerging insights of GPCR-miRNA network and their interaction in angiogenic pathways leading to the cancer progression. Alongside we have focused on the GPCR mediated angiogenic processes which are controlled by anti-angiogenicmiRNAs and the influence of deregulation of these miRNAs on cancer angiogenesis. Through an extensive literature survey, we identified 7 distinct miRNAs, which are playing important role in regulating angiogenesis. Through network analysis with predicted targets for reported miRNAs and pathway enrichment, 25 major cell signaling pathways associated with tumor-angiogenesis could be identified, further reinforcing the relevance of the miRNAs in the process.

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Acknowledgements

This work was supported by the Department of Science and technology (DST)-SERB grant (File Number: SRG/2020/002215) awarded to KP and Seed Grant, Adamas University awarded to AB and SH (Ref No. AU/REG/2019-20/12/008).

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Authors and Affiliations

  1. Department of Biochemistry, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal, India

    Samanwita Mandal, Deblina Chakrabarty & Srijan Haldar

  2. Department of Microbiology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal, India

    Arijit Bhattacharya

  3. Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal, India

    Joydeep Paul & Kuntal Pal

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  1. Samanwita Mandal
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  2. Deblina Chakrabarty
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  4. Joydeep Paul
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  5. Srijan Haldar
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  6. Kuntal Pal
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Contributions

SM: Processed the experimental data, and performed the analysis under guidance of AB. DC: Performed the Literature survey. AB: Involved in planning, processed the experimental data performed the analysis. JP: Conceived of the presented idea, performed the Literature survey,and processed the experimental data, involved in planning. Drafted the manuscript and designed the figures. SH: Conceived of the presented idea, performed the Literature survey, processed the experimental data, involved in planning, drafted the manuscript and designed the figures, supervised this work. KP: Conceived of the presented idea, performed the Literature survey, processed the experimental data, involved in planning, drafted the manuscript and designed the figures, supervised this work.

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Correspondence to Srijan Haldar or Kuntal Pal.

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Mandal, S., Chakrabarty, D., Bhattacharya, A. et al. miRNA regulation of G protein-coupled receptor mediated angiogenic pathways in cancer. Nucleus 64, 303–315 (2021). https://doi.org/10.1007/s13237-021-00365-0

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  • DOI: https://doi.org/10.1007/s13237-021-00365-0

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