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Development of Gelatin Thin Film Reinforced by Modified Gellan Gum and Naringenin-Loaded Zein Nanoparticle as a Wound Dressing

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Abstract

Today, the importance of biocompatible nanocomposite films with suitable properties for potential applications in wound healing has been considered. In present study, nanocomposite films of gelatin/aldehyde-gellan gum/Naringenin-loaded Zein nanoparticle (GL/AG/NR@Z) were successfully produced with the solution casting method. NR@Z with different concentrations (1.5 and 3 wt%) loaded into the GL/AG films. Then, the morphological, structural, thermal, and physical properties of these films were investigated. The obtained findings illustrated that by addition of NR@Z content a denser and more porous structure with high swelling ratio (around 80%), high thermal stability, high tensile stress (54.33 ± 3.45 MPa), and high weight loss (around 70%) was observed. Cell viability assessment of the produced films displayed no cytotoxicity for NIH3T3 fibroblast cells. Furthermore, since NR is a polyphenolic compound, the produced GL/AG/NR@Z nanocomposite films showed antioxidant and antibacterial activity. Consequently, we demonstrated that nanocomposite films (GL/AG/NR@Z) could be a suitable scaffold for wound healing applications.

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Authors and Affiliations

  1. Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Marjan Ghorbani

  2. Department of Biology, Islamic Azad University, Shiraz, Iran

    Nasrin Hassani

  3. Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Mortaza Raeisi

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  1. Marjan Ghorbani
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  2. Nasrin Hassani
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  3. Mortaza Raeisi
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Correspondence to Marjan Ghorbani.

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Acknowledgment: This study was supported by the Nutrition Research Center; Tabriz University of Medical Sciences (Grant number: 68080).

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Ghorbani, M., Hassani, N. & Raeisi, M. Development of Gelatin Thin Film Reinforced by Modified Gellan Gum and Naringenin-Loaded Zein Nanoparticle as a Wound Dressing. Macromol. Res. 30, 397–405 (2022). https://doi.org/10.1007/s13233-022-0049-1

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