Abstract
Polymer-based multifunctional composites have been increasingly employed in therapeutic applications such as bioartificial bone grafts, surgical sutures, drug carriers, and tissue scaffolds. Herein, the current work focuses on the fabrication of polycaprolactone/graphene oxide/strontium (PCL–GO–Sr) nanocomposite featuring distinctive physicochemical as well as biological attributes. The hybrid graphene oxide/strontium (GO–Sr) system was prepared via a simple electrostatic interaction approach and the nanohybrid-integrated PCL composite was cast into films. The findings of XRD, FTIR, XPS, SEM, EDAX, and Raman studies revealed that the Sr nanoparticles (SrNPs) are embedded well across the GO surface. Furthermore, using UV–Vis and PL analysis, the optical aspects of the GO–Sr system were investigated. The hemolytic assay affirms the biocompatible nature of the as-synthesized nanoparticulate system. Following that, the inclusion of such nanohybrids in the polymeric framework resulted in significant improvements in the tensile strength, surface wettability, and bioresorbability of the PCL nanocomposites. The nanocomposite displayed considerable biomineralization, minimal antibacterial efficacy, and ALP activity along with cytocompatibility owing to its significant bioactivity. Thus, the GO–Sr integrated PCL nanocomposite could be utilized to design multifaceted scaffolds, as an emerging biomaterial in tissue engineering, particularly for bone tissue regeneration.
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The authors express their heartfelt thanks to Karunya Institute of Technology and Sciences, Coimbatore, for providing valuable laboratory facilities in addition to characterization facilities.
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Joy, A., Unnikrishnan, G., Megha, M. et al. Design of biocompatible polycaprolactone-based nanocomposite loaded with graphene oxide/strontium nanohybrid for biomedical applications. Appl Nanosci 13, 4471–4484 (2023). https://doi.org/10.1007/s13204-022-02721-1
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DOI: https://doi.org/10.1007/s13204-022-02721-1