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Revision Thyroid Surgery

  • Review Article
  • Published:
Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

The incidence of recurrence in well-differentiated thyroid malignancies range from 10 to 30%. It is estimated that about 31–46% of patients with differentiated thyroid cancer will have the persistent disease and 1.2–6.8% will have structural recurrences during post-operative monitoring, depending on the initial therapy and prognostic variables. It is challenging to decide on treatment versus active monitoring following repeated or persistent tumour detection. The biological factors of the tumour and the patient guide us in the overall decision-making. Revision thyroid surgery is technically challenging. The morbidity encountered during the revision surgery is related to the anatomy of the region undergoing dissection, the degree of fibrosis and scarring from prior surgery and the operating surgeon’s experience. Successful comprehensive management of revision thyroid surgery needs a multi-disciplinary approach. This review article highlights the definition, indications for revision surgery, identification of recurrent disease, management of parathyroid and recurrent laryngeal nerves with neuromonitoring.

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References

  1. Mazzaferri EL, Jhiang SM (1994) Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 97(5):418–428

    Article  CAS  PubMed  Google Scholar 

  2. Hugo J, Robenshtok E, Grewal R, Larson S, Tuttle RM (2012) Recombinant human thyroid stimulating hormone–assisted radioactive iodine remnant ablation in thyroid cancer patients at intermediate to high risk of recurrence. Thyroid 22(10):1007–15

  3. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE et al (2016) 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid 26(1):1–133

    Article  PubMed  PubMed Central  Google Scholar 

  4. American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Hauger BR, Kloos RT, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid Off J Am Thyroid Assoc. 2009;19(11):1167–214.

  5. Pitoia F, Jerkovich F (2019) Dynamic risk assessment in patients with differentiated thyroid cancer. Endocr Relat Cancer 26(10):R553–R566

    Article  CAS  PubMed  Google Scholar 

  6. Spencer C, LoPresti J, Fatemi S (2014) How sensitive (second-generation) thyroglobulin measurement is changing paradigms for monitoring patients with differentiated thyroid cancer, in the absence or presence of thyroglobulin autoantibodies. Curr Opin Endocrinol Diabetes Obes 21(5):394–404

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Cherkaoui GS, Guensi A, Taleb S, Idir MA, Touil N, Benmoussa R, et al. Poorly differentiated thyroid carcinoma: a retrospective clinicopathological study. Pan Afr Med J [Internet]. 2015. [cited 2019 Oct 15];21. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546773/

  8. Wong H, Wong KP, Yau T, Tang V, Leung R, Chiu J et al (2012) Is there a role for unstimulated thyroglobulin velocity in predicting recurrence in papillary thyroid carcinoma patients with detectable thyroglobulin after radioiodine ablation? Ann Surg Oncol 19(11):3479–3485

    Article  PubMed  PubMed Central  Google Scholar 

  9. Miyauchi A, Kudo T, Miya A, Kobayashi K, Ito Y, Takamura Y et al (2011) Prognostic impact of serum thyroglobulin doubling-time under thyrotropin suppression in patients with papillary thyroid carcinoma who underwent total thyroidectomy. Thyroid 21(7):707–716

    Article  PubMed  Google Scholar 

  10. Tufano RP, Clayman G, Heller KS, Inabnet WB, Kebebew E, Shaha A et al (2015) Management of recurrent/persistent nodal disease in patients with differentiated thyroid cancer: a critical review of the risks and benefits of surgical intervention versus active surveillance. Thyroid Off J Am Thyroid Assoc 25(1):15–27

    Article  Google Scholar 

  11. Gray JL, Singh G, Uttley L, Balasubramanian SP (2018) Routine thyroglobulin, neck ultrasound and physical examination in the routine follow up of patients with differentiated thyroid cancer—where is the evidence? Endocrine 62(1):26–33

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ringel MD, Nabhan F (2013) Approach to follow-up of the patient with differentiated thyroid cancer and positive anti-thyroglobulin antibodies. J Clin Endocrinol Metab 98(8):3104–3110

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Spencer CA (2011) Clinical review: clinical utility of thyroglobulin antibody (TgAb) measurements for patients with differentiated thyroid cancers (DTC). J Clin Endocrinol Metab 96(12):3615–3627

    Article  CAS  PubMed  Google Scholar 

  14. Kwak JY, Han KH, Yoon JH, Moon HJ, Son EJ, Park SH et al (2011) Thyroid imaging reporting and data system for US features of nodules: a step in establishing better stratification of cancer risk. Radiology 260(3):892–899

    Article  PubMed  Google Scholar 

  15. Salmaslioğlu A, Erbil Y, Dural C, Işsever H, Kapran Y, Ozarmağan S et al (2008) Predictive value of sonographic features in preoperative evaluation of malignant thyroid nodules in a multinodular goiter. World J Surg 32(9):1948–1954

    Article  PubMed  Google Scholar 

  16. Leenhardt L, Erdogan MF, Hegedus L, Mandel SJ, Paschke R, Rago T et al (2013) 2013 European Thyroid Association guidelines for cervical ultrasound scan and ultrasound-guided techniques in the postoperative management of patients with thyroid cancer. Eur Thyroid J 2(3):147–159

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Lamartina L, Deandreis D, Durante C, Filetti S (2016) Endocrine tumours: imaging in the follow-up of differentiated thyroid cancer: current evidence and future perspectives for a risk-adapted approach. Eur J Endocrinol 175(5):R185-202

    Article  CAS  PubMed  Google Scholar 

  18. Scharpf J, Tuttle M, Wong R, Ridge D, Smith R, Hartl D et al (2016) Comprehensive management of recurrent thyroid cancer: an American Head and Neck Society consensus statement. Head Neck 38(12):1862–1869

    Article  PubMed  Google Scholar 

  19. Miah CF, Zaman JA, Simon M, Davidov T, Trooskin SZ. The utility of lymph node mapping sonogram and thyroglobulin surveillance in post thyroidectomy papillary thyroid cancer patients. Surgery. 2014;156(6):1491–6; discussion 1496–1497.

  20. Maxon HR (1999) Detection of residual and recurrent thyroid cancer by radionuclide imaging. Thyroid 9(5):443–446

    Article  CAS  PubMed  Google Scholar 

  21. Shindo ML, Caruana SM, Kandil E, McCaffrey JC, Orloff LA, Porterfield JR et al (2014) management of invasive well-differentiated thyroid cancer: an American Head and Neck Society consensus statement. AHNS consensus statement Head Neck 36(10):1379–1390

    PubMed  Google Scholar 

  22. Salvatori M, Biondi B, Rufini V (2015) Imaging in endocrinology: 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in differentiated thyroid carcinoma: clinical indications and controversies in diagnosis and follow-up. Eur J Endocrinol 173(3):R115-130

    Article  CAS  PubMed  Google Scholar 

  23. Gulec S (2017) The art and science of thyroid surgery in the age of genomics: 100 years after Theodor Kocher. Mol Imaging Radionucl Ther 26(Suppl 1):1–9

    Article  PubMed  PubMed Central  Google Scholar 

  24. Gourgiotis S, Moustafellos P, Dimopoulos N, Papaxoinis G, Baratsis S, Hadjiyannakis E (2006) Inadvertent parathyroidectomy during thyroid surgery: the incidence of a complication of thyroidectomy. Langenbecks Arch Surg 391(6):557–560

    Article  PubMed  Google Scholar 

  25. Lee NJ, Blakey JD, Bhuta S, Calcaterra TC (1999) Unintentional parathyroidectomy during thyroidectomy. Laryngoscope 109(8):1238–1240

    Article  CAS  PubMed  Google Scholar 

  26. Lin DT, Patel SG, Shaha AR, Singh B, Shah JP (2002) Incidence of inadvertent parathyroid removal during thyroidectomy. Laryngoscope 112(4):608–611

    Article  PubMed  Google Scholar 

  27. Ondik MP, McGinn J, Ruggiero F, Goldenberg D (2010) Unintentional parathyroidectomy and hypoparathyroidism in secondary central compartment surgery for thyroid cancer. Head & Neck: Journal for the Sciences and Specialties of the Head and Neck (4):462–6

  28. Manouras A, Markogiannakis H, Lagoudianakis E, Antonakis P, Genetzakis M, Papadima A et al (2008) Unintentional parathyroidectomy during total thyroidectomy. Head Neck 30(4):497–502

    Article  PubMed  Google Scholar 

  29. Gonçalves Filho J, Zafereo ME, Ahmad FI, Nixon IJ, Shaha AR, Vander Poorten V et al (2018) decision making for the central compartment in differentiated thyroid cancer. Eur J Surg Oncol 44(11):1671–1678

    Article  PubMed  Google Scholar 

  30. Lo CY, Lam KY (2001) Routine parathyroid autotransplantation during thyroidectomy. Surgery 129(3):318–323

    Article  CAS  PubMed  Google Scholar 

  31. Nishida T, Nakao K, Hamaji M, Kamiike W, Kurozumi K, Matsuda H (1997) Preservation of recurrent laryngeal nerve invaded by differentiated thyroid cancer. Ann Surg 226(1):85–91

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Falk SA, McCaffrey TV (1995) Management of the recurrent laryngeal nerve in suspected and proven thyroid cancer. Otolaryngol-Head Neck Surg Off J Am Acad Otolaryngol-Head Neck Surg 113(1):42–48

    Article  CAS  Google Scholar 

  33. Chiang F-Y, Wang L-F, Huang Y-F, Lee K-W, Kuo W-R (2005) Recurrent laryngeal nerve palsy after thyroidectomy with routine identification of the recurrent laryngeal nerve. Surgery 137(3):342–347

    Article  PubMed  Google Scholar 

  34. Wu C-W, Dionigi G, Barczynski M, Chiang F-Y, Dralle H, Schneider R et al (2018) International neuromonitoring study group guidelines 2018: Part II: Optimal recurrent laryngeal nerve management for invasive thyroid cancer-incorporation of surgical, laryngeal, and neural electrophysiologic data. Laryngoscope 128(Suppl 3):S18-27

    Article  PubMed  Google Scholar 

  35. Hermann M, Hellebart C, Freissmuth M (2004) Neuromonitoring in thyroid surgery: prospective evaluation of intraoperative electrophysiological responses for the prediction of recurrent laryngeal nerve injury. Ann Surg 240(1):9–17

    Article  PubMed  PubMed Central  Google Scholar 

  36. Timon CI, Rafferty M (1999) Nerve monitoring in thyroid surgery: is it worthwhile? Clin Otolaryngol Allied Sci 24(6):487–490

    Article  CAS  PubMed  Google Scholar 

  37. Pisanu A, Porceddu G, Podda M, Cois A, Uccheddu A (2014) Systematic review with meta-analysis of studies comparing intraoperative neuromonitoring of recurrent laryngeal nerves versus visualization alone during thyroidectomy. J Surg Res 188(1):152–161

    Article  PubMed  Google Scholar 

  38. Wu S-Y, Shen H-Y, Duh Q-Y, Hsieh C-B, Yu J-C, Shih M-L (2018) Routine intraoperative neuromonitoring of the recurrent laryngeal nerve to facilitate complete resection and ensure safety in thyroid cancer surgery. Am Surg Atlanta 84(12):1882–1888

    Google Scholar 

  39. Bai B, Chen W. Protective effects of intraoperative nerve monitoring (IONM) for recurrent laryngeal nerve injury in thyroidectomy: meta-analysis. Sci Rep [Internet]. 2018. [cited 2019 May 31];8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958090/

  40. Higgins TS, Gupta R, Ketcham AS, Sataloff RT, Wadsworth JT, Sinacori JT (2011) Recurrent laryngeal nerve monitoring versus identification alone on post-thyroidectomy true vocal fold palsy: a meta-analysis. Laryngoscope 121(5):1009–1017

    Article  PubMed  Google Scholar 

  41. Sanabria A, Silver CE, Suárez C, Shaha A, Khafif A, Owen RP et al (2013) Neuromonitoring of the laryngeal nerves in thyroid surgery: a critical appraisal of the literature. Eur Arch Oto-Rhino-Laryngol Off J Eur Fed Oto-Rhino-Laryngol Soc EUFOS Affil Ger Soc Oto-Rhino-Laryngol - Head Neck Surg 270(9):2383–2395

    Google Scholar 

  42. Zheng S, Xu Z, Wei Y, Zeng M, He J (2013) Effect of intraoperative neuromonitoring on recurrent laryngeal nerve palsy rates after thyroid surgery–a meta-analysis. J Formos Med Assoc Taiwan Yi Zhi 112(8):463–472

    Article  PubMed  Google Scholar 

  43. Rulli F, Ambrogi V, Dionigi G, Amirhassankhani S, Mineo TC, Ottaviani F et al (2014) Meta-analysis of recurrent laryngeal nerve injury in thyroid surgery with or without intraoperative nerve monitoring. Acta Otorhinolaryngol Ital Organo Uff Della Soc Ital Otorinolaringol E Chir Cerv-facc 34(4):223–229

    CAS  Google Scholar 

  44. Malik R, Linos D (2016) Intraoperative neuromonitoring in thyroid surgery: a systematic review. World J Surg 40(8):2051–2058

    Article  PubMed  Google Scholar 

  45. Lombardi CP, Carnassale G, Damiani G, Acampora A, Raffaelli M, De Crea C et al (2016) “The final countdown”: is intraoperative, intermittent neuromonitoring really useful in preventing permanent nerve palsy? Evidence from a meta-analysis Surgery 160(6):1693–1706

    PubMed  Google Scholar 

  46. Yang S, Zhou L, Lu Z, Ma B, Ji Q, Wang Y (2017) Systematic review with meta-analysis of intraoperative neuromonitoring during thyroidectomy. Int J Surg Lond Engl 39:104–113

    Article  Google Scholar 

  47. Scheumann GF, Seeliger H, Musholt TJ, Gimm O, Wegener G, Dralle H et al (1996) Completion thyroidectomy in 131 patients with differentiated thyroid carcinoma. Eur J Surg Acta Chir 162(9):677–684

    CAS  Google Scholar 

  48. Erbil Y, Bozbora A, Ademoglu E, Salmaslioglu A, Ozarmagan S (2008) Is timing important in thyroid re-operation? J Otolaryngol - Head Neck Surg J Oto-Rhino-Laryngol Chir Cervico-Faciale 37(1):56–64

    Google Scholar 

  49. Glockzin G, Hornung M, Kienle K, Thelen K, Boin M, Schreyer AG et al (2012) Completion thyroidectomy: effect of timing on clinical complications and oncologic outcome in patients with differentiated thyroid cancer. World J Surg 36(5):1168–1173

    Article  PubMed  Google Scholar 

  50. Tan MP, Agarwal G, Reeve TS, Barraclough BH, Delbridge LW (2002) Impact of timing on completion thyroidectomy for thyroid cancer. Br J Surg 89(6):802–804

    Article  CAS  PubMed  Google Scholar 

  51. Walgenbach S, Junginger T (2002) Is the timing of completion thyroidectomy for differentiated thyroid carcinoma prognostic significant? Zentralbl Chir 127(5):435–438

    Article  CAS  PubMed  Google Scholar 

  52. Salari B, Hammon RJ, Kamani D, Randolph GW (2017) Staged surgery for advanced thyroid cancers: safety and oncologic outcomes of neural monitored surgery. Otolaryngol-Head Neck Surg Off J Am Acad Otolaryngol-Head Neck Surg 156(5):816–821

    Article  Google Scholar 

  53. Schneider R, Sekulla C, Machens A, Lorenz K, Thanh PN, Dralle H (2016) Dynamics of loss and recovery of the nerve monitoring signal during thyroidectomy predict early post-operative vocal fold function. Head Neck 38(Suppl 1):E1144-1151

    Article  PubMed  Google Scholar 

  54. Périé S, Aït-Mansour A, Devos M, Sonji G, Baujat B, St Guily JL (2013) Value of recurrent laryngeal nerve monitoring in the operative strategy during total thyroidectomy and parathyroidectomy. Eur Ann Otorhinolaryngol Head Neck Dis 130(3):131–136

    Article  PubMed  Google Scholar 

  55. Al-Saif O, Farrar WB, Bloomston M, Porter K, Ringel MD, Kloos RT (2010) Long-term efficacy of lymph node reoperation for persistent papillary thyroid cancer. J Clin Endocrinol Metab 95(5):2187–2194

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Palme CE, Waseem Z, Raza SN, Eski S, Walfish P, Freeman JL (2004) Management and outcome of recurrent well-differentiated thyroid carcinoma. Arch Otolaryngol Head Neck Surg 130(7):819–824

    Article  PubMed  Google Scholar 

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Correspondence to Karthik Nagaraja Rao.

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Rao, K.N., Satpute, S., Nagarkar, N.M. et al. Revision Thyroid Surgery. Indian J Surg Oncol 13, 199–207 (2022). https://doi.org/10.1007/s13193-021-01467-6

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