Abstract
Introduction
Aspirin overdose causes acid–base disturbances and organ dysfunction. Management is guided by research reported over 50 years ago when chronic aspirin toxicity was common and accounted for significant morbidity. We investigate our experience of aspirin overdose and the effectiveness of charcoal and bicarbonate administration over 20 years.
Methods
This is a retrospective series of acute aspirin overdose from two toxicology units from January 2000 to September 2019. Acute aspirin ingestions > 3000 mg were identified in each unit’s database. Excluded were cases of chronic exposure, hospital presentation > 24 hours after ingestion, and cases without a salicylate concentration. Included in our analysis was demographic data, clinical effects, investigations, complications, and treatment.
Results
There were 132 presentations in 108 patients (79 females (73%)). The median age was 28 years (range: 13–93 years). The median dose ingested was 7750 mg (IQR: 6000–14,400 mg). There were 44 aspirin-only ingestions. Mild toxicity (nausea, vomiting, tinnitus or hyperventilation) occurred in 22 with a median dose of 160 mg/kg. Moderate toxicity (acid–base disturbance, confusion) occurred in 16 with a median ingested dose of 297 mg/kg. There were no cases of severe toxicity (coma or seizures) due to aspirin alone. The median peak salicylate concentration was 276 mg/L (IQR: 175–400 mg/L, range: 14–814 mg/L). There was a moderate association between dose ingested and peak concentration (Pearson r = 0.58; 95% CI 0.45–0.68). Activated charcoal was administered in 36 (27%) cases, which decreased the median peak salicylate concentration (34.2 to 24.8 mg/L/g (difference: 9.4, 95% CI: 1.0–13.1)). Bicarbonate was administered in 34 (26%) presentations, decreasing the median apparent elimination half-life from 13.4 to 9.3 h (difference: 4.2 h, 95% CI: 1.0–6.5 h).
Conclusions
Acute aspirin overdose caused only mild to moderate effects in this series. Early administration of activated charcoal decreased absorption and use of bicarbonate enhanced elimination.
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Funding
Geoff Isbister is supported by a NHMRC Senior Research Fellowship ID1061041.
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K.I. and G.I. conceived the study. K.I., C.H. and K.H. completed the data collection. K.I. and G.I. analyzed the data. K.I. drafted the manuscript, and all authors contributed substantially to its revision. K.I. takes responsibility for the paper as a whole.
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The authors declare no competing interests.
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Supervising Editor: Gillian A. Beauchamp, MD.
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Data from this study were presented at the virtual NACCT conference in October 2020 and also at the Toxicology and Poisoning Network Australasia (TAPNA) Annual Scientific Meeting in Newcastle, Australia, May 7, 2021.
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Isoardi, K.Z., Henry, C., Harris, K. et al. Activated Charcoal and Bicarbonate for Aspirin Toxicity: a Retrospective Series. J. Med. Toxicol. 18, 30–37 (2022). https://doi.org/10.1007/s13181-021-00865-0
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DOI: https://doi.org/10.1007/s13181-021-00865-0