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F-18 FDG PET/CT in NK/T-Cell Lymphoma that Progressed from Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

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Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome involving an uncontrolled immune response with variable triggers. HLH is rare but highly fatal, even with proper treatment; therefore, early recognition and diagnosis are crucial for management. Although the role of F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in HLH is poorly defined, it can provide valuable information on disease status and possible triggers. Herein, we report an F-18 FDG PET/CT study on a case of NK/T-cell lymphoma that progressed from Epstein-Barr virus-associated HLH.

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Acknowledgements

We would like to thank Editage (www.editage.co.kr) for English language editing.

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Authors and Affiliations

  1. Department of Nuclear Medicine & Molecular Imaging, Ajou University School of Medicine, Worldcup-ro 164, Suwon, Kyunggi-do, 16499, Republic of Korea

    Il-Hyun Kim, Young-Sil An, Su Jin Lee & Joon-Kee Yoon

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  1. Il-Hyun Kim
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  2. Young-Sil An
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  3. Su Jin Lee
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  4. Joon-Kee Yoon
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Contributions

The study was designed by Il-Hyun Kim. Material preparation and data collection were performed by Il-Hyun Kim and Joon-Kee Yoon. The image interpretation was performed by Il-Hyun Kim, Su Jin Lee, Young-Sil An, and Joon-Kee Yoon. The first draft of the manuscript was written by Il-Hyun Kim and Joon-Kee Yoon, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Joon-Kee Yoon.

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Competing Interests

Il-Hyun Kim, Young-Sil An, Su Jin Lee, and Joon-Kee Yoon declare that they have no competing interests.

Ethics Approval and Consent to Participate

This study was approved by the Institutional Review Board (AJIRB-MED-EXP-21) and has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. The institutional review board waived the need to obtain informed consent.

Consent for Publication

The institutional review board waived the need to obtain informed consent because of the anonymity and the retrospective nature of the study.

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Kim, IH., An, YS., Lee, S.J. et al. F-18 FDG PET/CT in NK/T-Cell Lymphoma that Progressed from Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis. Nucl Med Mol Imaging 56, 59–62 (2022). https://doi.org/10.1007/s13139-021-00725-3

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  • DOI: https://doi.org/10.1007/s13139-021-00725-3

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