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Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy

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Abstract

Stroke is a debilitating condition which is also the second leading cause of death and disability worldwide. Despite the benefits and promises shown by numerous neuroprotective agents in animal stroke models, their clinical translation has not been a complete success. Hence, search for treatment options have directed researchers towards utilising stem cells. Mitochondria has a major involvement in the pathophysiology of stroke and a number of other conditions. Stem cells have shown the ability to transfer mitochondria to the damaged cells and to help revive cell energetics in the recipient cell. The present review discusses how stem cells could be employed to protect neurons and mitochondria in stroke and also the various mechanisms involved in neuroprotection.

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Funding

The authors acknowledge the Department of Science and Technology (DST), Govt. of India, for their financial support through grant (SB/YS/LS-196/2014), International Society for Neurochemistry (ISN) Return Home grant, Department of Pharmaceuticals, Ministry of Chemical and Fertilisers, Govt of India and National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gandhinagar, India. The authors also want to express their thanks to the Director, NIPER Ahmedabad, for providing necessary support.

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Authors and Affiliations

  1. Department or Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India

    Deepaneeta Sarmah, Harpreet Kaur, Jackson Saraf, Kanchan Vats, Kanta Pravalika, Madhuri Wanve, Kiran Kalia & Pallab Bhattacharya

  2. Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar, Assam, India

    Anupom Borah

  3. Department of Botany, Banaras Hindu University, Varanasi, India

    Akhilesh Kumar

  4. Department of Neurosurgery, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA

    Xin Wang

  5. Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA

    Dileep R. Yavagal & Kunjan R. Dave

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  1. Deepaneeta Sarmah
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  10. Xin Wang
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Correspondence to Pallab Bhattacharya.

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Sarmah, D., Kaur, H., Saraf, J. et al. Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy. Transl. Stroke Res. 10, 121–136 (2019). https://doi.org/10.1007/s12975-018-0642-y

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  • DOI: https://doi.org/10.1007/s12975-018-0642-y

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