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Green Synthesized Titanium Dioxide Nanoparticle from Aloe Vera Extract as a Promising Candidate for Radiosensitization Applications

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Abstract

Radiosensitizers have played a key role in the enhancement of radiation therapy to minimize the effect of ionizing radiation on healthy tissue. Different types of radiosensitizers had been developed and utilized in radiation therapy such as hyperbaric oxygen, carbogen, mitomycin-C, and fluorodeoxyuridine. With the development of nanotechnology, attention had been paid to produce nano-radiosensitizers such as gold, silver, titanium, gadolinium, and iron, silicon NPs to overcome the side effects of chemical radiosensitizers. In this manuscript, TiO2 NPs had been synthesized using different concentrations (10 ml, 20 ml, and 30 ml) of aloe vera extract. The physicochemical characteristics Of TiO2 NPs were characterized by X-ray diffraction (XRD), UV–vis spectroscopy (UV), RAMAN, Fourier transformation infrared (FTIR), and thermogravimetric analysis (TGA). MTT assay was used to assess the cytotoxicity of the samples under investigation before and after irradiation. The obtained results revealed aloe vera extract can be used as a reducing agent to synthesis of TiO2 NPs; also, the concentration of aloe vera extract is a key factor in the size and bioactivity of TiO2 NPs. Moreover, the green synthesis of TiO2 NPs enhances its biocompatibility as indicated in the decrease of its cytotoxicity to HepG2 cells. The green synthesized TiO2 NPs from aloe vera extract showed a promising radiosensitization ability with a dose- and concentration-dependent manner.

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Data Availability

All the data used to support the findings of this study are included within the article. Other data are available from the corresponding author upon request.

Abbreviations

NPs:

Nanoparticles

ROS:

Reactive oxygen species

ROS:

Titanium isopropoxide

PEG:

Polyethylene glycol

HepG2:

Liver hepatocellular cells

DMSO:

Dimethylsulfoxide

OD:

Optical density

XRD:

X-ray diffraction

FWHM:

Full width at half maximum

HRTEM:

High-resolution transmission electron microscope

FTIR:

Fourier transformation infrared

TGA:

Thermogravimetric analysis

DMEM:

Dulbecco’s Modified Eagle’s Medium

MTT:

3-[4,5-Dimethylthiazol-2-yl]-2,5 diphenyltetrazolium

SSD:

Source surface distance

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Funding

This research was supported financially by the Academy of Scientific Research and Technology (ASRT), Egypt, Grant No 6658.

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Authors and Affiliations

  1. Physics Department, Faculty of Science, South Valley University, Qena, 83523, Egypt

    N. K. Ahmed & A. Abbady

  2. Electronics and Nano Devices Lab, Faculty of Science, South Valley University, Qena, 83523, Egypt

    Yasmin Abo Elhassan & Alaa Hassan Said

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  1. N. K. Ahmed
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  2. A. Abbady
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Contributions

Yasmin Abo Elhassan did the experimental part and Alaa Hassan Said analyzed the data and wrote the original manuscript. N. K. Ahmed, A. Abbady revised the original manuscript. All authors read and approved the final manuscript.

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Correspondence to Alaa Hassan Said.

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Ahmed, N.K., Abbady, A., Elhassan, Y.A. et al. Green Synthesized Titanium Dioxide Nanoparticle from Aloe Vera Extract as a Promising Candidate for Radiosensitization Applications. BioNanoSci. 13, 730–743 (2023). https://doi.org/10.1007/s12668-023-01085-2

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