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Prothrombotic states in portal vein thrombosis and Budd-Chiari syndrome in India: A systematic review and meta-analysis

  • Systematic review with meta-analysis
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Abstract

Background

Both Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT) have been linked to various prothrombotic (PT) conditions. The PT profile in Asians is different from the west and there are no nationwide epidemiological surveys from India. Hence, the present meta-analysis was aimed at analyzing the prevalence of acquired and hereditary thrombophilia among Indian patients with non-cirrhotic PVT and BCS.

Methods

A comprehensive literature search of Embase, Medline and Scopus was conducted from January 2000 to February 2022 for studies evaluating the prevalence of various PT conditions in Indian patients with PVT and BCS. Pooled prevalence rates across studies were expressed with summative statistics.

Results

Thirty-five studies with 1005 PVT patients and 1391 BCS patients were included in the meta-analysis. At least one PT condition was seen in 46.2% (28.7–63.7) of the PVT patients and 44.9% (37.3–60.7) of the BCS patients. Multiple PT conditions were seen in 13.0% (4.2–21.8) of the PVT patients and 7.9% (3.5–12.4) of the BCS patients. Among PVT patients, hyperhomocysteinemia was the commonest prothrombotic condition (21.6%) followed by protein C (PC) deficiency (10.7%), Janus kinase 2 (JAK-2) mutation (8.5%) and antiphospholipid antibodies (APLA) (7.5%). Among patients with BCS, PC deficiency was the commonest prothrombotic condition (10.6%) followed by methylenetetrahydrofolate reductase (MTHFR) mutation (9.8%), APLA (9.7%) and JAK-2 mutation (9.1%).

Conclusion

The PT profile in Indian patients with abdominal vein thrombosis is different from that of the western data with a lower prevalence of PT conditions in patients with BCS.

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Authors and Affiliations

  1. Department of Gastroenterology, Nizam’s Institute of Medical Sciences, 4th Floor, Specialty Block, Panjagutta, Hyderabad, 500 082, India

    Suprabhat Giri, Sumaswi Angadi & Sukanya Bhrugumalla

  2. Department of Gastroenterology, K M Cherian Institute of Medical Sciences, Kallissery, 689 124, India

    Jijo Varghese

  3. Department of Digestive Disease and Clinical Nutrition, Tata Memorial Hospital, Parel, Mumbai, 400 012, India

    Sridhar Sundaram

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  1. Suprabhat Giri
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Contributions

Conceptualization: S. G., S. S.; data curation: S. G., S. A., J. V.; formal analysis: S. G., S. A., J. V.; funding acquisition: N/A; investigation: S. G., S. S.; methodology: S. G., S. S., S. A., S. B.; project administration: S. S., S. B.; resources: S. G., S. A., J. V.; software: S. G.; supervision; S. S., S. B.; validation: S. G., S. S.; visualization: S. G.; roles/writing—original draft: S. G., S. A., S. S., S. B.; writing—review and editing: S. G., S. A., J. V., S. S., S. B.

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Correspondence to Sukanya Bhrugumalla.

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SG, SA, JV, SS and SB declare no competing interests.

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Giri, S., Angadi, S., Varghese, J. et al. Prothrombotic states in portal vein thrombosis and Budd-Chiari syndrome in India: A systematic review and meta-analysis. Indian J Gastroenterol 42, 629–641 (2023). https://doi.org/10.1007/s12664-023-01400-5

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