Abstract
Purpose
This retrospective study aimed to investigate the effect of frequent computed tomography (CT) examinations with contrast media on the renal function of patients with oral squamous cell cancer (OSCC) that underwent radical surgery, by using estimated glomerular filtration rate (eGFR); to identify risk factors of occurrence of post-operative chronic kidney disease (CKD) in these patients; and to explore the relationship between risk factors and occurrence of postoperative CKD during follow-up.
Methods
Herein, 188 patients (107 male; 81 female) who underwent radical surgery for OSCC were included. We evaluated the risk factors for postoperative CKD after treatment, including demographic, perioperative, and postoperative factors by univariate and multivariate analyses. Patients were divided into post-operative CKD and control groups based on eGFR evaluation. Overall survival (OS) rates were compared between the groups.
Results
eGFR decreased over time after treatment in both patient groups. Postoperative CKD was diagnosed in 56 (29.8%) patients. The average number of contrast-enhanced CT examinations was not an independent risk factor for postoperative CKD. However, lower hemoglobin on hospital discharge [odds ratio (OR) = 0.53], lower eGFR on hospital discharge (OR = 0.84), and common use of nonsteroidal anti-inflammatory drugs (OR = 48.79) were significant risk factors associated with postoperative CKD. The control group was associated with a better OS than the postoperative CKD group; however, this difference was not significant.
Conclusions
Clinicians should pay close attention to these risk factor of post-operative CKD during the management of patients with OSCC that undergo radical surgery and frequent follow-up CT examinations with contrast media.
Similar content being viewed by others
References
HoriM, Matsuda T, Shibata A, Katanoda K, Sobue T, Nishimoto H, Japan Cancer Surveillance Research Group (2015) Cancer incidence and incidence rates in Japan in 2009: a study of 32 population-based cancer registries for the Monitoring of Cancer Incidence in Japan (MCIJ) project. Jpn J Clin Oncol 45(9):884–891
Kalavrezos N, Bhandari R (2010) Current trends and future perspectives in the surgical management of oral cancer. Oral Oncol 46:429–432
Kernohan MD, Clark JR, Gao K, Ebrahimi A, Milross CG (2010) Predicting the prognosis of oral squamous cell carcinoma after first recurrence. Arch Otolaryngol Head Neck Surg 136:1235–1239
Huang TY, Hsu LP, Wen YH et al (2010) Predictors of locoregional recurrence in early stage oral cavity cancer with free surgical margins. Oral Oncol 46:49–55
National Comprehensive Cancer Network. Clinical practice guidelines in oncology. Head and Neck Cancers. Version 2. 2022
The Japanese Society of Oral Oncology. Japanese Clinical Practice Guideline for Oral Cancer, 2013
Marchant FE, Lowry LD, Moffitt JJ, Sabbagh R (1993) Current national trends in the posttreatment follow-up of patients with squamous cell carcinoma of the head and neck. Am J Otolaryngol 14(2):88–93
Paniello RC, Virgo KS, Johnson MH, Clemente MF, Johnson FE (1999) Practice patterns and clinical guidelines for posttreatment follow-up of head and neck cancers: a comparison of 2 professional societies. Arch Otolaryngol Head Neck Surg 125:309e13
Digonnet A, Hamoir M, Andry G, Haigentz M Jr, Takes RP, Silver CE, Hartl DM, Strojan P, Rinaldo A, de Bree R, Dietz A, Grégoire V, Paleri V, Langendijk JA, Vander Poorten V, Hinni ML, Rodrigo JP, Suárez C, Mendenhall WM, Werner JA, Genden EM, Ferlito A (2013) Post-therapeutic surveillance strategies in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol 270(5):1569–1580
Daisne JF, Duprez T, Weynand B, Lonneux M, Hamoir M, Reychler H, Grégoire V (2004) Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen. Radiology 233(1):93–100
Hermans R, Pameijer FA, Mancuso AA, Parsons JT, Mendenhall WM (2000) Laryngeal or hypopharyngeal squamous cell carcinoma: can follow-up CT after definitive radiation therapy be used to detect local failure earlier than clinical examination alone? Radiology 214(3):683–687
Lee J, Cho JY, Lee HJ, Jeong YY, Kim CK, Park BK, Sung DJ, Kang BC, Jung SI, Lee EJ, Yi BH, Park SJ, Kim JC, Jung DC, Sung CK, Kim Y, Lee Y, Kim SH, Yoon SK, Park BJ, Kim SH; Korean Society of Urogenital Radiology (KSUR); Korean Society of Radiology (2014) Contrast-induced nephropathy in patients undergoing intravenous contrast-enhanced computed tomography in Korea: a multi-institutional study in 101487 patients. Korean J Radiol 15(4):456–463
Ohno I, Hayashi H, Aonuma K, Horio M, Kashihara N, Okada H, Komatsu Y, Tamura S, Awai K, Yamashita Y, Kuwatsuru R, Hirayama A, Saito Y, Murohara T, Tamaki N, Sato A, Takayama T, Imai E, Yasuda Y, Koya D, Tsubakihara Y, Horie S, Korogi Y, Narumi Y, Hayakawa K, Daida H, Node K, Kubota I; Japanese Society of Nephrology, Japan Radiological Society, and Japanese Circulation Society Science Advisory and Coordinating Committee (2013) Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version : JSN, JRS, and JCS Joint Working Group. Clin Exp Nephrol 17(4):441–479
Moos SI, van Vemde DN, Stoker J, Bipat S (2013) Contrast induced nephropathy in patients undergoing intravenous (IV) contrast enhanced computed tomography (CECT) and the relationship with risk factors: a meta-analysis. Eur J Radiol 82(9):e387–e399
Japanese Society of Nephrology (2019) Essential points from evidence-based clinical practice guidelines for chronic kidney disease 2018. Clin Exp Nephrol 3(1):1–15
Kaplan C, Pasternack B, Shah H, Gallo G (1975) Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol 80(2):227–234
Jhee SS, Burm JP, Gill MA (1994) Comparison of aminoglycoside pharmacokinetics in Asian, Hispanic, and Caucasian patients by using population pharmacokinetic methods. Antimicrob Agents Chemother 38(9):2073–2077
Nishimura G, Tsukuda M, Horiuchi C, Satake K, Yoshida T, Taguchi T, Nagao J, Kawakami M, Kondo N, Matsuda H, Mikami Y (2007) Decrease of creatinine clearance rate with aging in patients with head and neck cancer in Japan. Int J Clin Oncol 12(2):120–124
Homma A, Hayashi R, Kawabata K, Fujii T, Iwae S, Hasegawa Y, Nibu K, Kato T, Shiga K, Matsuura K, Monden N, Fujii M (2016) Association of impaired renal function and poor prognosis in oropharyngeal squamous cell carcinoma. Head Neck 38(10):1495–1500
Morcos R, Kucharik M, Bansal P, Al Taii H, Manam R, Casale J, Khalili H, Maini B (2019) Contrast-induced acute kidney injury: review and practical update. Clin Med Insights Cardiol 13:1179546819878680
Geenen RW, Kingma HJ, van der Molen AJ (2013) Contrast-induced nephropathy: pharmacology, pathophysiology and prevention. Insights Imaging 4(6):811–820
Tsai WC, Wu HY, Peng YS, Ko MJ, Wu MS, Hung KY, Wu KD, Chu TS, Chien KL (2016) Risk factors for development and progression of chronic kidney disease: a systematic review and exploratory meta-analysis. Medicine (Baltimore) 95(11):e3013
Whelton A, Maurath CJ, Verburg KM, Geis GS (2000) Renal safety and tolerability of celecoxib, a novel cyclooxygenase-2 inhibitor. Am J Ther 7(3):159–175
Pope JE, Anderson JJ, Felson DT (1993) A meta-analysis of the effects of nonsteroidal anti-inflammatory drugs on blood pressure. Arch Intern Med 153(4):477–484
Silverberg D, Wexler D, Blum M, Wollman Y, Iaina A (2003) The cardio-renal anaemia syndrome: does it exist? Nephrol Dial Transplant Suppl 8:viii7–12. Review
Fine LG, Bandyopadhay D, Norman JT (2000) Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia. Kidney Int Suppl 75:S22–S26
Schrier RW, Shapiro JI, Chan L, Harris DC (1994) Increased nephron oxygen consumption: potential role in progression of chronic renal disease. Am J Kidney Dis 23(2):176–182
Acknowledgements
We thank Cathel Kerr, BSc, PhD, from Edanz Group (https://en-author-services.edanzgroup.com/) for editing a draft of this manuscript.
Funding
No funding was received for this study, including institutional or departmental support.
Author information
Authors and Affiliations
Contributions
Study design: T Hasegawa, A Kimoto, A Sakakibara, M Akashi; Acquisition of data: T Hasegawa, A Matsuda, R Amano, I Saito; Analysis and interpretation of data: T Hasegawa, D Takeda, Y Kakei; Manuscript preparation: T Hasegawa, A Kimoto, A Sakakibara, M Akashi; Manuscript editing: T Hasegawa, A Matsuda, R Amano, I Saito, D Takeda, Y Kakei, A Kimoto, A Sakakibara, M Akashi; Manuscript review: T Hasegawa, A Matsuda, R Amano, I Saito, D Takeda, Y Kakei, A Kimoto, A Sakakibara, M Akashi; Statistical analysis: T Hasegawa.
Corresponding author
Ethics declarations
Conflict of interest
All authors declare that they have no conflict of interest.
Ethical approval
Due to the retrospective nature of this study, informed consent was not required. Instead, we published the information of the study protocol and granted patients with the opportunity of refusing to participate in this study. This retrospective study has been conducted in full accordance with the tenets of the World Medical Association Declaration of Helsinki and was approved by the Institutional Review Board of Kobe University Graduate School of Medicine (Authorization number: 200025).
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Hasegawa, T., Matsuda, A., Amano, R. et al. Effect of Frequent Computed Tomography Examinations with Contrast Media on the Renal Function of Patients with Oral Squamous Cell Cancer and an Evaluation of Risk Factors for Post-Operative Chronic Kidney Disease. J. Maxillofac. Oral Surg. (2023). https://doi.org/10.1007/s12663-023-02015-1
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s12663-023-02015-1