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Apigenin effect against Leishmania tropica amastigotes in vitro

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Abstract

Cutaneous Leishmaniasis is a current public health problem in Syria. It causes different skin lesions that vary in their severity from spontaneously heal lesions to permanent deformity ones. However, the used treatments have many disadvantages as their high toxicity and many side effects. Flavonoids including Apigenin reported to have many anti parasitic properties. As well as their preference as potential therapeutic alternatives in the treatment of Leishmaniasis due to its low side effects and toxicity. This study aims to evaluate the efficacy of Apigenin against L.tropica amastigotes in vitro using Leishmania-Macrophage Interaction Assay. Our study demonstrated the possibility of efficacy of Apigenin against L.tropica amastigotes since Apigenin reduced the infection index at IC50 60.44 µM and this requires subsequent studies in humans and using Apigenin as a candidate for the chemotherapeutic treatment against Leishmaniasis.

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Authors and Affiliations

  1. Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria

    Nagham Naddaf & Shaden Haddad

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  1. Nagham Naddaf
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  2. Shaden Haddad
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Correspondence to Nagham Naddaf.

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Dr. Naddaf has nothing to disclose. Dr. Haddad has nothing to disclose.

Ethical statement

All procedures performed in our study were in accordance with the care and use for animals protocol of Center for Epidemiological and Biological Studies of Leishmania Parasites in Damascus University.

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Naddaf, N., Haddad, S. Apigenin effect against Leishmania tropica amastigotes in vitro. J Parasit Dis 44, 574–578 (2020). https://doi.org/10.1007/s12639-020-01230-8

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  • DOI: https://doi.org/10.1007/s12639-020-01230-8

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