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Preparation and Characterization of Inorganic Organic Hybrid Material Based on TEOS/MAPTMS for Biomedical Applications

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Abstract

In this study, inorganic-organic hybrid material consisting of tetraethyl orthosilicate (TEOS) and 3-methacryloxypropyl trimethoxysilane (MAPTMS) were prepared with sol-gel process and evaluated as a bioactive bone substitute. The hydrolysis and condensation were attained in an (ethanol/water) solution. Different molar ratios of TEOS/MAPTMS [(1:0), (1:1), (1:2), (1:3) and (1:4)] [M0, M1, M2, M3, M4] respectively were proposed. The molar proportion of silane to water to ethanol was 1:3:3. Bioactivity of all samples was studied via in-vitro test by immersion in simulated body fluid (SBF) to evaluate the creation of a calcium phosphate (CP) layer on the surface of specimens. Structural characterization of the prepared samples was performed using X -ray diffraction (XRD) and fourier transform infrared (FTIR) spectroscopy while the morphology of the samples was examined using scanning electron microscopy (SEM) equipped with an energy dispersive x-ray analysis (EDXA). Results showed the formation of a layer of hydroxyl apatite (HA) on the surface of all samples. As the polymer amount increases the nucleation sites and surface porosity increase, which improve the bioactivity of the sample surface. HA layer increased with increasing the concentration of MAPTMS.

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References

  1. El hadad AA, Carbonell D, Barranco V, Jiménez-Morales A, Casal B, Galván JC (2011) Preparation of sol–gel hybrid materials from γ-methacryloxypropyltrimethoxysilane and tetramethyl orthosilicate: study of the hydrolysis and condensation reactions. Colloid Polym Sci 289(17–18):1875–1883. https://doi.org/10.1007/s00396-011-2504-y

    Article  CAS  Google Scholar 

  2. Alcantara-garcia A, Garcia-casas A, Jimenez-morales A (2019) Progress in organic coatings the effect of the organosilane content on the barrier features of sol-gel anticorrosive coatings applied on carbon steel. Prog Org Coatings (September):105418. https://doi.org/10.1016/j.porgcoat.2019.105418

  3. Melia G, Moghal J, Hicks C, Oubaha M, Mccormack D, Duffy B (2016) Investigation of the mechanical and thermal fatigue properties of hybrid sol – gel coatings applied to AA2024 substrates. J Coatings Technol Res 13(6):1083–1094. https://doi.org/10.1007/s11998-016-9821-5

    Article  CAS  Google Scholar 

  4. Chattopadhyay DK, Webster DC (2009) Hybrid coatings from novel silane-modified glycidyl carbamate resins and amine crosslinkers. Prog Org Coatings 66(1):73–85. https://doi.org/10.1016/j.porgcoat.2009.06.004

    Article  CAS  Google Scholar 

  5. Kayan A (2019) Inorganic-organic hybrid materials and their adsorbent properties. Adv Compos Hybrid Mater 2(1):34–45. https://doi.org/10.1007/s42114-018-0073-y

    Article  CAS  Google Scholar 

  6. Schottner G (2001) Hybrid sol - gel-derived polymers : applications of multifunctional materials. Chem Mater 13:3422–3435. https://doi.org/10.1021/cm011060m

    Article  CAS  Google Scholar 

  7. Sanchez C, Julián B, Belleville P, Popall M (2005) Applications of hybrid organic-inorganic nanocomposites. J Mater Chem 15(35–36):3559–3592. https://doi.org/10.1039/b509097k

    Article  CAS  Google Scholar 

  8. Casal B, Ruiz-Hitzky E, Crespin M, Tinet D, Galván JC (1989) Intercalation mechanism of nitrogenated bases into V<inf>2</inf>O<inf>5</inf> xerogel. J Chem Soc Faraday Trans 1 Phys Chem Condens Phases 85(12):4167–4177. https://doi.org/10.1039/F19898504167

    Article  CAS  Google Scholar 

  9. Ruiz-Hitzky E, Aranda P, Casal B, Galván JC (1995) Nanocomposite materials with controlled ion mobility. Adv Mater 7(2):180–184. https://doi.org/10.1002/adma.19950070218

    Article  CAS  Google Scholar 

  10. Wang J, Merino J, Aranda P, Galván JC, Ruiz-Hitzky E (1999) Reactive nanocomposites based on pillared clays. J Mater Chem 9(1):161–168. https://doi.org/10.1039/a804861d

    Article  CAS  Google Scholar 

  11. Ruiz-Hitzky E, Casal B, Aranda P, Galván JC (2001) Inorganic -organic nanocomposite materials based on macrocyclic compounds 21(1–2)

  12. Rojas-Cervantes ML, Casal B, Aranda P, Savirón M, Galvaán JC, Ruiz-Hitzky E (2001) Hybrid materials based on vanadium pentoxide intercalation complexes. Colloid Polym Sci 279(10):990–1004. https://doi.org/10.1007/s003960100531

    Article  CAS  Google Scholar 

  13. Nicole L, Boissière C, Grosso D, Quach A, Sanchez C (2005) Mesostructured hybrid organic-inorganic thin films. J Mater Chem 15(35–36):3598–3627. https://doi.org/10.1039/b506072a

    Article  CAS  Google Scholar 

  14. Amarilla JM, Casal B, Ruiz-Hitzky E, Galvan JC (1992) Lithium-MVO5 (M = Nb, Ta) bronzes. Chem Mater 4(1):62–67. https://doi.org/10.1021/cm00019a015

    Article  CAS  Google Scholar 

  15. Galván JC, Aranda P, Amarilla JM, Casal B, Ruiz-Hitzky E (1993) Organosilicic membranes doped with crown-ethers. J Mater Chem 3(6):687–688. https://doi.org/10.1039/JM9930300687

    Article  Google Scholar 

  16. Aranda P, Jiménez-Morales A, Galván JC, Casal B, Ruiz-Hitzky E (1995) Composite membranes based on macrocycle/polysiloxanes: preparation, characterization and electrochemical behaviour. J Mater Chem 5(6):817–825. https://doi.org/10.1039/jm9950500817

    Article  Google Scholar 

  17. A. C. Society, “From : Date : To : Cc : Bcc : Subject : ‘ Felipe Maia ’ Carol News Pessoal , Ontem eu fui no Supermercado pela primeira vez .... como ainda nao estou familiarizada com os danoninhos , chambinho , yakult , etc , acabei me divertindo com outros itens ... En,” vol. 864, no. 1, p. 608418, 2012

  18. Lev O et al (1997) Sol-gel materials in electrochemistry. Chem Mater 9(11):2354–2375. https://doi.org/10.1021/cm970367b

    Article  CAS  Google Scholar 

  19. Wang B, Li B, Deng Q, Dong S (1998) Amperometric glucose biosensor based on sol - gel organic - inorganic hybrid material 70(15):3170–3174

  20. Walcarius A (2001) Electrochemical applications of silica-based organic-inorganic hybrid materials. Chem Mater 13(10):3351–3372. https://doi.org/10.1021/cm0110167

    Article  CAS  Google Scholar 

  21. Walcarius A, Mandler D, Cox JA, Lev O (2005) Exciting new directions in the intersection of functionalized sol – gel materials with electrochemistry:3663–3689. https://doi.org/10.1039/b504839g

  22. Popall M, Andrei M, Kappel J, Kron J, Olma K, Olsowski B (1998) ORMOCERs as inorganic-organic electrolytes for new solid state lithium batteries and supercapacitors. Electrochim Acta 43(10–11):1155–1161. https://doi.org/10.1016/S0013-4686(97)10014-7

    Article  CAS  Google Scholar 

  23. Zheludkevich ML, Salvado IM, Ferreira MGS (2005) Sol-gel coatings for corrosion protection of metals. J Mater Chem 15(48):5099–5111. https://doi.org/10.1039/b419153f

    Article  CAS  Google Scholar 

  24. Barranco V, Carmona N, Galván JC, Grobelny M, Kwiatkowski L, Villegas MA (2010) Electrochemical study of tailored sol-gel thin films as pre-treatment prior to organic coating for AZ91 magnesium alloy. Prog Org Coatings 68(4):347–355. https://doi.org/10.1016/j.porgcoat.2010.02.009

    Article  CAS  Google Scholar 

  25. Owen MJ (2013) 3-Methacryloxypropyltrimethoxysilane. ACS Symp Ser 1154:47–56. https://doi.org/10.1021/bk-2013-1154.ch004

    Article  CAS  Google Scholar 

  26. Park OH, Eo YJ, Choi YK, Bae BS (1999) Preparation and optical properties of silica-poly(ethylene oxide) hybrid materials. J Sol-Gel Sci Technol 16(3):235–241. https://doi.org/10.1023/A:1008717219952

    Article  CAS  Google Scholar 

  27. Pizzi A, Mittal KL (2003) Silane and other adhesion promoters in adhesive technology. Handb Adhes Technol:205–221

  28. Kokubo T, Ito S, Huang ZT, Hayashi T, Sakka S, Kitsugi T, Yamamuro T (Mar. 1990) Ca, P-rich layer formed on high-strength bioactive glass-ceramic A-W. J Biomed Mater Res 24(3):331–343. https://doi.org/10.1002/jbm.820240306

    Article  CAS  PubMed  Google Scholar 

  29. Nariyal RK, Kothari P, Bisht B (2014) FTIR measurements of SiO2 glass prepared by sol-gel technique. Chem Sci Trans 3(3):1064–1066. https://doi.org/10.7598/cst2014.816

    Article  CAS  Google Scholar 

  30. Kumar M, Tripathi BP, Shahi VK (2009) Ionic transport phenomenon across sol-gel derived organic-inorganic composite mono-valent cation selective membranes. J Memb Sci 340(1–2):52–61. https://doi.org/10.1016/j.memsci.2009.05.010

    Article  CAS  Google Scholar 

  31. Bansal NP (1992) Low temperature synthesis of CaO-Si02 glasses having stable liquid-liquid immiscibility by sol-gel process. J Mater Sci 27(11):2922–2933. https://doi.org/10.1007/BF01154101

    Article  CAS  Google Scholar 

  32. Innocenzi P, Brusatin G (2004) A comparative FTIR study of thermal and photo-polymerization processes in hybrid sol-gel films. J Non-Cryst Solids 333(2):137–142. https://doi.org/10.1016/j.jnoncrysol.2003.09.043

    Article  CAS  Google Scholar 

  33. Pantoja M, Díaz-Benito B, Velasco F, Abenojar J, del Real JC (2009) Analysis of hydrolysis process of ??-methacryloxypropyltrimethoxysilane and its influence on the formation of silane coatings on 6063 aluminum alloy. Appl Surf Sci 255(12):6386–6390. https://doi.org/10.1016/j.apsusc.2009.02.022

    Article  CAS  Google Scholar 

  34. Examiners ST, Kellom M, J. M. Examiners, and N. S. Council (2015) Aida Khayyami low temperature sol-gel on polymeric substrate

  35. Rodi P, Mertelj A, Borov M, Ben A, Mihailovi D, Milo I (2016) Surface & coatings technology composition , structure and morphology of hybrid acrylate-based sol – gel coatings containing Si and Zr composed for protective applications 286:388–396. https://doi.org/10.1016/j.surfcoat.2015.12.036

  36. Alay Aksoy S, Alkan C, Tözüm MS, Demirbağ S, Altun Anayurt R, Ulcay Y (2017) Preparation and textile application of poly(methyl methacrylate-co-methacrylic acid)/n-octadecane and n-eicosane microcapsules. J Text Inst 108(1):30–41. https://doi.org/10.1080/00405000.2015.1133128

    Article  CAS  Google Scholar 

  37. Rodi P, Milo I, Lekka M, Andreatta F, Fedrizzi L (2018) Progress in organic coatings corrosion behaviour and chemical stability of transparent hybrid sol-gel coatings deposited on aluminium in acidic and alkaline solutions (February). https://doi.org/10.1016/j.porgcoat.2018.02.025

  38. Brigo L, Pistore A, Grenci G, Carpentiero A, Romanato F, Brusatin G (2010) New hybrid organic-inorganic sol-gel positive resist. Microelectron Eng 87(5–8):947–950. https://doi.org/10.1016/j.mee.2009.11.151

    Article  CAS  Google Scholar 

  39. Matinlinna JP, Özcan M, Lassila LVJ, Vallittu PK (2004) The effect of a 3-methacryloxypropyltrimethoxysilane and vinyltriisopropoxysilane blend and tris(3-trimethoxysilylpropyl)isocyanurate on the shear bond strength of composite resin to titanium metal. Dent Mater 20(9):804–813. https://doi.org/10.1016/j.dental.2003.10.009

    Article  CAS  PubMed  Google Scholar 

  40. Teresa OH, Choi CK (2010) Comparison between SiOC thin film by plasma enhance chemical vapor deposition and SiO2 thin film by Fourier transform infrared spectroscopy. J Korean Phys Soc 56(4):1150–1155. https://doi.org/10.3938/jkps.56.1150

    Article  CAS  Google Scholar 

  41. Paljar K, Orlić S, Tkalčec E, Ivanković H (2006) Characterization of organic-inorganic hybrids prepared from poly(methyl methacrylate) and organically modified Si – alkoxyde. Chem Eng:158–165

  42. Cheng YL, Yeh CC, Li KF, Yan CJ, Chen CC, Hong FCN (2015) Synthesis and applications of functionalized polysiloxane nanoparticles uniformly dispersed in UV-cured resin. 2015 10th Int. Microsystems, Packag. Assem. Circuits Technol. Conf. IMPACT 2015 - Proc., no 1, pp 362–364. https://doi.org/10.1109/IMPACT.2015.7365249

  43. Costantini G, Luciani G, Annunziata BS, Branda F (2006) Swelling properties and bioactivity of silica gel/pHEMA nanocomposites. J Mater Sci Mater Med 17(4):319–325. https://doi.org/10.1007/s10856-006-8230-1

    Article  CAS  PubMed  Google Scholar 

  44. Chajri S et al (2015) Studies on preparation and characterization of SiO2-CaO-P2O5 and SiO2-CaO-P2O5-Na2O bioglasses subtituted with ZnO 6:1882–1897

  45. Wang W, Weng D, Wu X (2012) Structure evolution and thermal stability of La2O3-doped mullite fibers via sol-gel method. J Rare Earths 30(2):175–180. https://doi.org/10.1016/S1002-0721(12)60018-0

    Article  CAS  Google Scholar 

  46. Shen S, Hu D, Sun P, Zhang X, Parikh AN (2009) Amino acid catalyzed bulk-phase gelation of organoalkoxysilanes via a transient co-operative self-assembly. J Phys Chem B 113(41):13491–13498. https://doi.org/10.1021/jp905069j

    Article  CAS  PubMed  Google Scholar 

  47. Milošev I, Kapun B, Rodič P, Iskra J (2015) Hybrid sol–gel coating agents based on zirconium(IV) propoxide and epoxysilane. J Sol-Gel Sci Technol 74(2):447–459. https://doi.org/10.1007/s10971-015-3620-9

    Article  CAS  Google Scholar 

  48. Liao W, Qu J, Li Z, Chen H (2010) Preparation of organic/inorganic hybrid polymer emulsions with high silicon content and sol-gel-derived thin films. Chin J Chem Eng 18(1):156–163. https://doi.org/10.1016/S1004-9541(08)60337-7

    Article  CAS  Google Scholar 

  49. Berzina-Cimdina L, Borodajenko N (2012) Research of calcium phosphates using Fourier transform infrared spectroscopy. Infrared Spectrosc Mater Sci Eng Technol. https://doi.org/10.5772/36942

  50. Lee TM, Chang E, Wang BC, Yang CY (1996) Characteristics of plasma-sprayed bioactive glass coatings on Ti-6Al-4V alloy: an in vitro study. Surf Coat Technol 79(1–3):170–177. https://doi.org/10.1016/0257-8972(95)02463-8

    Article  CAS  Google Scholar 

  51. Zakaria FA et al Preparation of carbonated apatite and its evaluation. Proc Mater Process Med Devices Conf Novemb 14–16, 2005, Boston, Massachusetts, USA, pp 43–48, 2006

  52. Miraz S, Rafie M, Nordin D (2017) Synthesis and characterization of hydroxyapatite nanoparticle (Sintesis dan Pencirian Nanozarah Hidrosiapatit). Malaysian J Anal Sci 21(1):136–148. https://doi.org/10.17576/mjas-2017-2101-16

    Article  Google Scholar 

  53. Manoj M, Subbiah R, Mangalaraj D, Ponpandian N, Viswanathan C, Park K (2015) Influence of growth parameters on the formation of hydroxyapatite (HAp) nanostructures and their cell viability studies. Nanobiomedicine 2:2. https://doi.org/10.5772/60116

    Article  PubMed  PubMed Central  Google Scholar 

  54. Rodriguez MA, Liso MJ, Rubio F, Rubio J, Oteo JL (1999) Study of the reaction of γ-methacryloxypropyltrimethoxysilane (γ-MPS) with slate surfaces. J Mater Sci 34(16):3867–3873. https://doi.org/10.1023/A:1004666621479

    Article  CAS  Google Scholar 

  55. Liang J, Hu Y, Wu Y, Chen H (2014) Facile formation of superhydrophobic silica-based surface on aluminum substrate with tetraethylorthosilicate and vinyltriethoxysilane as co-precursor and its corrosion resistant performance in corrosive NaCl aqueous solution. Surf Coatings Technol 240:145–153. https://doi.org/10.1016/j.surfcoat.2013.12.028

    Article  CAS  Google Scholar 

  56. De Microscopie L, Analytique E, De Lyon EC (2005) Synthesis and structural analysis of sol gel derived 27–31

  57. Woo KM, Seo J, Zhang R, Ma PX (2007) Suppression of apoptosis by enhanced protein adsorption on polymer/hydroxyapatite composite scaffolds. Biomaterials 28(16):2622–2630. https://doi.org/10.1016/j.biomaterials.2007.02.004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Bouhekka A, Bürgi T (2012) Photodegradation of adsorbed bovine serum albumin on TiO2 anatase investigated by In-Situ ATR-IR spectroscopy 59

  59. Healy KE, Ducheyne P (1992) Hydration and preferential molecular adsorption on titanium in vitro. Biomaterials 13(8):553–561. https://doi.org/10.1016/0142-9612(92)90108-Z

    Article  CAS  PubMed  Google Scholar 

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  1. Physics Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, 11884, Egypt

    A. S. Abdraboh, Ahmed A. Abdel-Aal & Khairy T. Ereiba

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Abdraboh, A.S., Abdel-Aal, A.A. & Ereiba, K.T. Preparation and Characterization of Inorganic Organic Hybrid Material Based on TEOS/MAPTMS for Biomedical Applications. Silicon 13, 613–622 (2021). https://doi.org/10.1007/s12633-020-00460-y

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