Skip to main content
Log in

Overview of the Biomolecular Association and Dynamics session at the 20th IUPAB congress, 45th Brazilian congress of SBBF, and the 50th annual meeting of SBBq

  • Commentary
  • Published:
Biophysical Reviews Aims and scope Submit manuscript

Abstract

In this session, experts in molecular biophysics described the dynamics of biopolymers across a wide range of length and time scales. This discussion highlighted numerous techniques that span from highly detailed simulations, to coarse-grained theoretical models, as well as high-resolution structural analysis. The topics were equally diverse, where there was discussion of biological processes at small (individual atoms), intermediate (assemblies) and very large scales (phase separation).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1:

References

  • Dans PD, Balaceanu A, Pasi M, Patelli AS, Petkeviciute D, Walther J, Hospital A, Bayarri G, Lavery R, Maddocks JH, Orozco M (2019) The static and dynamic structural heterogeneities of B-DNA: extending Calladine-Dickerson rules. Nucleic Acids Res 47:11090–11102. https://doi.org/10.1093/nar/gkz905

  • Dans PD, Ivani I, Hospital A, Portella G, Gonzalez C, Orozco M (2017) How accurate are accurate force-fields for B-DNA? Nucleic Acids Res 45:4217–4230. https://doi.org/10.1093/nar/gkw1355

  • as S, Lin YH, Vernon RM, Forman-Kay JD, Chan HS (2020) Comparative roles of charge, pi, and hydrophobic interactions in sequence-dependent phase separation of intrinsically disordered proteins. Proc Natl Acad Sci U S A 117:28795–28805. https://doi.org/10.1073/pnas.2008122117

  • Leven I, Levy Y (2019) Quantifying the two-state facilitated diffusion model of protein-DNA interactions. Nucleic Acids Res 47:5530–5538. https://doi.org/10.1093/nar/gkz308 

  • Levi M, Noel JK, Whitford PC (2019) Studying ribosome dynamics with simplified models. Methods 162–163:128–140. https://doi.org/10.1016/j.ymeth.2019.03.023

  • Loveland AB, Demo G, Grigorieff N, Korostelev AA (2017) Ensemble cryo-EM elucidates the mechanism of translation fidelity. Nature 546:113–117. https://doi.org/10.1038/nature22397 

  • Loveland AB, Demo G, Korostelev AA (2020) Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading. Nature 584:640–645.  https://doi.org/10.1038/s41586-020-2447-x

  • Pal Tanmoy, Wessén Jonas, Das Suman, Chan Hue Sun (2021) Subcompartmentalization of polyampholyte species in organelle-like condensates is promoted by charge-pattern mismatch and strong excluded-volume interaction. Physical Review E 103:042406. https://doi.org/10.1103/PhysRevE.103.042406

  • Vuzman D, Polonsky M, Levy Y (2010) Facilitated DNA search by multidomain transcription factors: cross talk via a flexible linker. Biophys J 99:1202–1211.  https://doi.org/10.1016/j.bpj.2010.06.007

  • Xu EH, Rould MA, Wenqing Xu, Epstein JA, Maas RL, Pabo CO (1999) Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. Genes Dev 13:1263–1275.  https://doi.org/10.1101/gad.13.10.1263

Download references

Funding

PCW was supported by NSF grant MCB-1915843. This work was supported by the Center for Theoretical Biological Physics sponsored by the NSF (Grant PHY-2019745).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paul Charles Whitford.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Whitford, P.C. Overview of the Biomolecular Association and Dynamics session at the 20th IUPAB congress, 45th Brazilian congress of SBBF, and the 50th annual meeting of SBBq. Biophys Rev 13, 863–865 (2021). https://doi.org/10.1007/s12551-021-00884-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12551-021-00884-9

Navigation