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Vitamin D therapy in pediatric patients with inflammatory bowel disease: a systematic review and meta-analysis

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Abstract

Background

There is some evidence for the role of vitamin D deficiency in the pathogenesis of inflammatory bowel disease (IBD) in the pediatric population. However, the results are contradictory. Therefore, we have conducted a systematic review and meta-analysis to evaluated the effect of vitamin D on pediatric patients with IBD.

Methods

We carried out a systematic search in databases from inception until 20 January 2022. We included all relevant articles that evaluate the efficacy and safety of vitamin D on disease activity, inflammatory factors, and vitamin D and calcium levels in pediatric patients with IBD. Random effects models were used to combine the data. The main outcomes were then analyzed using weight mean difference (WMD) and respective 95% confidence interval (CI).

Results

Fifteen treatment arms met the eligibility criteria and were included. Pooled estimates indicated that intervention with vitamin D has a significantly beneficial effect on 25-hydroxyvitamin D3 [25(OH) D3] (pooled WMD of 17.662 ng/mL; CI 9.77–25.46; P < 0.001), calcium (pooled WMD of 0.17 mg/dL; CI 0.04–0.30; P = 0.009), and inflammatory factors including C-reactive protein (CRP) (pooled WMD of −6.57 mg/L; CI −11.47 to −1.67; P = 0.009) and erythrocyte sedimentation rate (ESR) (pooled WMD of −7.94 mm/h; CI −12.65 to −3.22; P = 0.001) levels. In addition, this effect was greater for vitamin D levels at doses greater than 2000 IU, and when follow-up duration was more than 12 weeks.

Conclusion

This study showed that vitamin D therapy can have a significant and beneficial effect on 25(OH) D3, calcium, and inflammatory factors in children and adolescents with IBD.

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Data availability

Data are available on request due to privacy/ethical restrictions.

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Funding

This research was supported by grant No. 1401-1-249-57731 from the Tehran University of Medical Sciences. The funding body had no role in designing the study and did not take part in data collection, data analysis, interpretation of the data, or writing of the manuscript.

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Authors and Affiliations

  1. Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Hassan Sohouli, Fatemeh Farahmand, Hosein Alimadadi, Parisa Rahmani, Farzaneh Motamed & Pejman Rohani

  2. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Hassan Sohouli

  3. Postgraduate Programme in Collective Health, Federal University of Maranhão, Rua Barão de Itapary, 155, Centro, São Luís, MA, Brazil

    Elma Izze da Silva Magalhães

  4. Pediatrics Gastroenterology, Department of Pediatrics, School of Medicine, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Pejman Rohani

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  1. Mohammad Hassan Sohouli
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Contributions

RP, SMH: conception, design, statistical analysis, data collection, writing–original draft, supervision. MF, AH, ME, FF: data collection and writing–original draft. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Pejman Rohani.

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Ethical approval

The study protocol was ethically approved by the Regional Bioethics Committee of Tehran University of Medical Sciences (No: IR.TUMS.CHMC.REC.1401.060).

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Sohouli, M.H., Farahmand, F., Alimadadi, H. et al. Vitamin D therapy in pediatric patients with inflammatory bowel disease: a systematic review and meta-analysis. World J Pediatr 19, 48–57 (2023). https://doi.org/10.1007/s12519-022-00605-6

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  • DOI: https://doi.org/10.1007/s12519-022-00605-6

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