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Relationship of monocyte chemoattractant protein 1 (MCP-1) with insulin resistance and body mass index, but not with thermogenetic hormones in obesity

  • Original Article
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Mediterranean Journal of Nutrition and Metabolism

Abstract

Monocyte chemoattractant protein 1 (MCP-1) has been implicated in the recruitment of monocytes to atheroma and of monocytes and macrophages to adipose tissue. The aim of the study was to examine whether MCP-1 levels are associated independently with the main thermogenetic hormones (serum TSH and thyroid hormones and 24-h urinary catecholamines) and insulin resistance in a population mainly represented by overweight and obese women. A cohort of 100 consecutive euthyroid women, aged 18–65 years, and with a wide range of BMI, was examined. Central fat accumulation (indirectly measured by waist circumference), fasting MCP-1 plasma levels, and TSH, FT3, FT4, insulin, glucose, and lipid (cholesterol, HDL-cholesterol and triglyceride) serum concentrations, and 24-h urinary catecholamines were measured. Insulin resistance was estimated by homeostasis model assessment (HOMAIR). MCP-1 levels were directly associated with BMI (p < 0.001), waist circumference (p < 0.001), insulin (p < 0.001), HOMAIR (p < 0.001), diastolic blood pressure (DBP) (p < 0.001), systolic blood pressure (SBP) (p < 0.001), triglycerides (TG) (p < 0.05), and 24-h urinary noradrenaline (p < 0.05), and negatively correlated with HDL-cholesterol (p < 0.01). When a multiple regression analysis was performed with MCP-1 as the dependent variable, and only parameters showing a significant univariate association with MCP-1 were considered as the independent variables, MCP-1 maintained an independent positive association with insulin (p < 0.01), and DBP (p < 0.05). When insulin was replaced by HOMAIR in the regression analysis, MCP-1 maintained an independent positive association with HOMAIR (p < 0.05), DBP (p < 0.05), and BMI (p < 0.05). In conclusion, this study suggests that insulin, BMI, and diastolic blood pressure cooperate independently in increasing MCP-1 levels, whereas thyroid hormones and catecholamines have no apparent influence on this chemokine.

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Authors and Affiliations

  1. Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, School of Medicine, Policlinico, University of Bari, Piazza Giulio Cesare, 74124, Bari, Italy

    Giovanni De Pergola, Rosalba Amoroso, Alida Ammirati, Domenico Caccavo, Federica Meleca & Claudia Centoducati

  2. Endocrinology Section, Ospedale S.S. Annunziata, 74100, Taranto, Italy

    Marcello Sciaraffia

  3. Laboratorio Analisi, IRCCS, Ospedale Oncologico, Bari, Italy

    Michele Quaranta

  4. Via Putignani 236, 70122, Bari, Italy

    Giovanni De Pergola

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  1. Giovanni De Pergola
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  2. Marcello Sciaraffia
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Correspondence to Giovanni De Pergola.

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De Pergola, G., Sciaraffia, M., Amoroso, R. et al. Relationship of monocyte chemoattractant protein 1 (MCP-1) with insulin resistance and body mass index, but not with thermogenetic hormones in obesity. Mediterr J Nutr Metab 3, 137–142 (2010). https://doi.org/10.1007/s12349-010-0005-z

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  • DOI: https://doi.org/10.1007/s12349-010-0005-z

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