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A case of focal nodular hyperplasia with hepatic failure treated with liver transplantation

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Abstract

Focal nodular hyperplasia (FNH) is a benign nodular lesion, but because of its feature of portal tract vessel abnormality, it may induce portal hypertension. A 27-year-old woman was admitted with a fever. A large nodule with satellite lesions was found in the liver and cotton wool-like feature of arteries were detected on angiography. Technetium galactosyl serum albumin scintigraphy and diagnostic laparoscopy showed that the tumor site was functional, while the surrounding area was a non-functional fibrotic area. A biopsy specimen indicated that the nodular lesion was an FNH-like lesion. She experienced several instances of variceal rupture and suffered liver failure, receiving liver transplantation. The excised liver showed a centrally scarred area in the nodule, indicating that the diagnosis was FNH. We herein report this case as a rare case of FNH that progressed to liver failure.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Tetsuya Yasunaka, Yasuto Takeuchi, Akinobu Takaki, Atsushi Oyama, Takuya Adachi, Nozomu Wada, Hideki Onishi, Hidenori Shiraha & Hiroyuki Okada

  2. Department of Pathology, School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan

    Fukuo Kondo

  3. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka, 812-8582, Japan

    Tomoharu Yoshizumi

  4. Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka, 812-8582, Japan

    Kenichi Kohashi

Authors
  1. Tetsuya Yasunaka
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  2. Yasuto Takeuchi
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  3. Akinobu Takaki
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  4. Fukuo Kondo
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  5. Tomoharu Yoshizumi
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  6. Kenichi Kohashi
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  7. Atsushi Oyama
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  8. Takuya Adachi
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  9. Nozomu Wada
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  10. Hideki Onishi
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  11. Hidenori Shiraha
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  12. Hiroyuki Okada
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Contributions

TY participated in the actual diagnosis and treatment of the case, data analysis, and writing of the paper; YT participated in the writing of the paper; AT participated in the actual diagnosis and treatment of the case, data analysis, and writing of the paper; FK and KK participated in the pathological diagnosis; TY participated in the liver transplantation and post-transplantation care for the case; AO, TA, NW, HO, and HS participated in the actual diagnosis and treatment of the case; HO participated in the actual writing of the paper

Corresponding author

Correspondence to Akinobu Takaki.

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Conflict of interest

Tetsuya Yasunaka, Yasuto Takeuchi, Akinobu Takaki, Fukuo Kondo, Tomoharu Yoshizumi, Kenichi Kohashi, Atsushi Oyama, Takuya Adachi, Nozomu Wada, Hideki Onishi, Hidenori Shiraha and Hiroyuki Okada declare that they have no conflict of interest.

Human/animal rights

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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We could not earn informed consent from the patient because she cannot be traced now. This case report does not contain identifying information of the patient.

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Yasunaka, T., Takeuchi, Y., Takaki, A. et al. A case of focal nodular hyperplasia with hepatic failure treated with liver transplantation. Clin J Gastroenterol 15, 171–176 (2022). https://doi.org/10.1007/s12328-021-01529-w

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  • DOI: https://doi.org/10.1007/s12328-021-01529-w

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