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Colonic clear cell adenocarcinoma with enteroblastic differentiation

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Abstract

Adenocarcinoma with enteroblastic differentiation (ACED) has high malignant potential. It is known as clear-cell adenocarcinoma, which is a special type of adenocarcinomas characterized by primitive intestine-like structures. Although ACED is often encountered in the stomach, it is very rare in the colon and has not been sufficiently reported. ACED has also not been described in the WHO and Japanese Colonic Carcinoma Classification. ACED has biological characteristics of easy metastasis and a poor prognosis than these of tubular adenocarcinoma. Therefore, all cases of colonic ACED that have been reported previously required either surgery or chemotherapy. We describe a case of flat-elevated-type and 15 mm in size colonic ACED that was successfully treated with endoscopic submucosal dissection. We report our case along with a relevant literature review.

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Authors and Affiliations

  1. Division of Gastroenterology, St. Luke’s International Hospital, 9-1 Akashi-cho Chuo-ku, Tokyo, 104-8340, Japan

    Yasutoshi Shiratori & Takashi Ikeya

  2. Division of Pathology, St. Luke’s International Hospital, Tokyo, Japan

    Koyu Suzuki

Authors
  1. Yasutoshi Shiratori
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  2. Koyu Suzuki
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  3. Takashi Ikeya
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Contributions

YS performed the therapeutic endoscopy. YS and TI managed the patient. YS drafted the manuscript. YS, KS, and TI edited and revised the manuscript.

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Correspondence to Yasutoshi Shiratori.

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The authors declare that they have no conflict of interest.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).

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Informed consent was obtained from all patients to be included in the study.

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Shiratori, Y., Suzuki, K. & Ikeya, T. Colonic clear cell adenocarcinoma with enteroblastic differentiation. Clin J Gastroenterol 13, 1196–1199 (2020). https://doi.org/10.1007/s12328-020-01209-1

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  • DOI: https://doi.org/10.1007/s12328-020-01209-1

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