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Cerebellar Microstructural Abnormalities in Obsessive–Compulsive Disorder (OCD): a Systematic Review of Diffusion Tensor Imaging Studies

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Abstract

Previous neuroimaging studies have suggested that obsessive–compulsive disorder (OCD) is associated with altered resting-state functional connectivity of the cerebellum. In this study, we aimed to describe the most significant and reproducible microstructural abnormalities and cerebellar changes associated with obsessive–compulsive disorder (OCD) using diffusion tensor imaging (DTI) investigations. PubMed and EMBASE were searched for relevant studies using the PRISMA 2020 protocol. A total of 17 publications were chosen for data synthesis after screening titles and abstracts, full-text examination, and executing the inclusion criteria. The patterns of cerebellar white matter (WM) integrity loss, determined by fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) metrics, varied across studies and symptoms. Changes in fractional anisotropy (FA) values were described in six publications, which were decreased in four and increased in two studies. An increase in diffusivity parameters of the cerebellum (i.e., MD, RD, and AD) in OCD patients was reported in four studies. Alterations of the cerebellar connectivity with other brain areas were also detected in three studies. Heterogenous results were found in studies that investigated cerebellar microstructural abnormalities in correlation with symptom dimension or severity. OCD’s complex phenomenology may be characterized by changes in cerebellar WM connectivity across wide networks, as shown by DTI studies on OCD patients in both children and adults. Classification features in machine learning and clinical tools for diagnosing OCD and determining the prognosis of the disorder might both benefit from using cerebellar DTI data.

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Acknowledgements

We sincerely thank the authors of the included articles in this systematic review due to sharing the relevant data.

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Author notes

  1. Parnian Shobeiri and Sedighe Hosseini Shabanan contributed equally.

Authors and Affiliations

  1. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Parnian Shobeiri & Shaghayegh Khanmohammadi

  2. NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Parnian Shobeiri & Maryam Haghshomar

  3. Non–Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Parnian Shobeiri & Shaghayegh Khanmohammadi

  4. Department of Radiology, University of California San Diego, San Diego, CA, USA

    Sedighe Hosseini Shabanan & Soudabeh Fazeli

  5. Department of Radiology, Northwestern University, Chicago, IL, USA

    Maryam Haghshomar

  6. Department of Radiology and Neurology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA

    Houman Sotoudeh

  7. Department of Diagnostic and Interventional Radiology, University of Texas McGovern Medical School, Houston, TX, USA

    Arash Kamali

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Contributions

Conceptualization: PS and MH; literature search and data extraction: PS and SHS; formal analysis and investigation: SHS; writing—original draft preparation: PS, SHS, MH, and SK; writing—review and editing: SF, HS, AK, and SK. All authors have read and approved the final manuscript.

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Correspondence to Parnian Shobeiri.

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Shobeiri, P., Hosseini Shabanan, S., Haghshomar, M. et al. Cerebellar Microstructural Abnormalities in Obsessive–Compulsive Disorder (OCD): a Systematic Review of Diffusion Tensor Imaging Studies. Cerebellum 23, 778–801 (2024). https://doi.org/10.1007/s12311-023-01573-x

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