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Role of Epigenetic Modification in the Intergeneration Transmission of War Trauma

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Abstract

War trauma has been linked to changes in the neuroendocrine and immunological systems and increases the risk of physical disorders. Traumatic events during the war may have long-term repercussions on psychological and biological parameters in future generations, implying that traumatic stress may have transgenerational consequences. This article addresses how epigenetic mechanisms, which are a key biological mechanism for dynamic adaptation to environmental stressors, may help explain the long-term and transgenerational consequences of trauma. In war survivors, epigenetic changes in genes mediating the hypothalamus–pituitary–adrenal axis, as well as the immune system, have been reported. These genetic modifications may cause long-term changes in the stress response as well as physical health risks. Also, the finding of biomarkers for diagnosing the possibility of psychiatric illnesses in people exposed to stressful conditions such as war necessitates extensive research. While epigenetic research has the potential to further our understanding of the effects of trauma, the findings must be interpreted with caution because epigenetic molecular mechanisms is only one piece of a complicated puzzle of interwoven biological and environmental components.

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  1. Clinical Biochemistry Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Ayeh Bolouki

  2. Research Unit on Cellular Biology (URBC), University of Namur, Namur, Belgium

    Ayeh Bolouki

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Bolouki, A. Role of Epigenetic Modification in the Intergeneration Transmission of War Trauma. Ind J Clin Biochem (2023). https://doi.org/10.1007/s12291-023-01136-1

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