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Metabolic Syndrome and Body Composition Among People Aged 50 Years and Over: Results from The Neyshabur Longitudinal Study on Ageing (NeLSA)

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Abstract

There are few studies regarding body composition and metabolic syndrome (MetS) association in older adults. To evaluate the association between MetS and body composition indices in a large-scale population of subjects with an age of 50 and up. This study was based on the data from Neyshabur Longitudinal Study on Ageing (NeLSA) in a total of 7462 people of Neyshabur city in IRAN. The best cut-off scores and AUC value of body composition variables for having association with likelihood of MetS were determined by using a receiver operating curve analysis. Each unit increase in the Waist/Hip ratio, the odds of having MetS increase 3–6 times (OR: 4.937, 95%CI: 3.930, 6.203 in men; OR: 3.322, 95%CI: 2.259, 4.884 in women). In addition, in the case of BMI (OR: 1.256, 95% Cl: 1.226, 1.286 in men; OR: 1.104, 95% Cl: 1.086, 1.121 in women) and BFM (OR: 1.119, 95% Cl: 1.105, 1.133 in men; OR: 1.050, 95% Cl: 1.041, 1.060 in women), the chance of having MetS increases with increasing these variables. Totally, BMI and BFM showed the best AUC values. The optimal cut-off values for BMI in men was 26.45 and in women was 27.35 and for BFM in men was 23.35 and in women was 26.85. These results suggest that adiposity measures such as BMI and BFM are associated with likelihood of having MetS in subjects with an age of 50 and up, and that avoiding high adiposity is important to prevent MetS incidence.

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Acknowledgements

This article was based on the data from Neyshabur Longitudinal Study on Ageing (NeLSA). The authors would like to thank all those who helped us during this project including colleagues at Neyshabur Universities of Medical Sciences and Neyshabur Healthy Ageing Research Centre.

Funding

NeLSA has been partly funded by Neyshabur University of Medical Sciences. The Iranian Ministry of Health and Medical education has also contributed to the funding used in the PERSIAN Cohorts through Grant no 700/534.

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Authors and Affiliations

  1. Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran

    Mohsen Azimi-Nezhad, Nayyereh Aminisani, Ahmad Ghasemi, Azam Rezaei Farimani & Seyed Morteza Shamshirgaran

  2. Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

    Azam Rezaei Farimani

  3. Department of Epidemiology and Biostatistics, Neyshabur University of Medical Sciences, Neyshabur, Iran

    Fatemeh Khorashadizadeh

  4. Non-communicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran

    Seyed Reza Mirhafez

  5. Centre for Innovative Ageing, College of Human and Health Sciences, Swansea University, Swansea, Wales, UK

    Martin Hyde

Authors
  1. Mohsen Azimi-Nezhad
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  2. Nayyereh Aminisani
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  3. Ahmad Ghasemi
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  4. Azam Rezaei Farimani
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  6. Seyed Reza Mirhafez
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  7. Martin Hyde
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  8. Seyed Morteza Shamshirgaran
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Corresponding author

Correspondence to Ahmad Ghasemi.

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The authors declare that they have no competing interests.

Human and animal rights

The current study was performed with full respect to human rights. NeLSA has been approved by the Ethical Committee of Neyshabur University of Medical Sciences (IR.NUMS.REC, 1394.35) and the PERSIAN cohort study ethics approval by Tehran University of Medical Sciences (IR.TUMS.DDRI.REC.1396.1). The current study received an approval from Neyshabur University of Medical Sciences (IR.NUMS.REC.1398.41).

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The written informed consent was obtained from all participants and they were free to leave the study at any time and for any reason, without any consequences.

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Azimi-Nezhad, M., Aminisani, N., Ghasemi, A. et al. Metabolic Syndrome and Body Composition Among People Aged 50 Years and Over: Results from The Neyshabur Longitudinal Study on Ageing (NeLSA). Ind J Clin Biochem 37, 432–440 (2022). https://doi.org/10.1007/s12291-021-01014-8

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  • DOI: https://doi.org/10.1007/s12291-021-01014-8

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