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The Usability of Platelet Mass Index Thresholds to Assess the Repeated Platelet Transfusion Requirements in Neonates

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Abstract

To evaluate the usability of platelet mass index (PMI) thresholds to assess the repeated platelet transfusion requirements in neonates who have received transfusion within the previous six days. This is a retrospective cross-sectional study conducted with neonates who received prophylactic platelet transfusion. The PMI was calculated as platelet count (× 1000/mm3) × mean platelet volume (MPV) (fL). Platelet transfusions were divided into two groups as first (Group 1) and repeated transfusions (Group 2). The increment and percentage of increment in platelet counts, MPV and PMI after transfusion were compared between the two groups. The amounts of changes were calculated as: (Post-transfusion) − (Pre-transfusion values). The percentages of changes were calculated as: ([Post-transfusion − Pre-transfusion values]/Pre-tansfusion values) × 100. Eighty three platelet transfusions were analyzed in 28 neonates. The median gestational age and birth weight were 34.5 (26–37) weeks, and 2225 (752.5–2937.5) grams, respectively. There were 20 (24.1%) transfusions in Group 1, and 63 (75.9%) transfusions in Group 2. There were no differences in the amounts of changes in platelet counts, MPV and PMI between the groups (p > 0.05). When the percentages of changes were analyzed, it was found that the platelet counts and PMI in Group 1 increased to a greater extent compared to Group 2 (p = 0.026, p = 0.039, respectively), but no significant difference was found in MPV between the groups (p = 0.081). The lower percentage of change in PMI in Group 2 was associated with the lower percentage of change in platelet counts. Being transfused with adult platelets did not affect platelet volume of the neonates. Therefore, PMI thresholds can be used in neonates with a history of platelet transfusion.

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Funding

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Authors and Affiliations

  1. Neonatal Intensive Care Unit, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey

    Asli Okbay Gunes, Suleyman Geter & Mehmet Emin Avlanmis

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  1. Asli Okbay Gunes
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  2. Suleyman Geter
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  3. Mehmet Emin Avlanmis
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by AOG, SG and MEA. The first draft of the manuscript was written by AOG, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Asli Okbay Gunes.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Consent for Publication

The Research Ethics Committee approved our request to publish anonymized data for this study.

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Due to the retrospective nature of the study, no patient consent was required for this study.

Ethics Approval

This study was performed in line with the principles of the Declaration of Helsinki. The study protocol was approved by Harran University Clinical Research Ethics Committee (date: 24.05.2021, number: 21.10.22).

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Okbay Gunes, A., Geter, S. & Avlanmis, M.E. The Usability of Platelet Mass Index Thresholds to Assess the Repeated Platelet Transfusion Requirements in Neonates. Indian J Hematol Blood Transfus 39, 464–469 (2023). https://doi.org/10.1007/s12288-022-01604-3

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  • DOI: https://doi.org/10.1007/s12288-022-01604-3

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