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Is it Worthwhile to Undergo the Extended Stage Assessment in Orbital and Ocular Adnexal MALT Lymphoma with Symptoms Limited to the Ocular Adnexa?

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Compared to ocular adnexal lymphoma of mucosa-associated lymphoid tissue-type (OAML) patients with symptoms related invasion beyond the ocular adnexa, the different approaches to staging assessment may be required in OAML patients with symptoms limited to the ocular adnexa. Seventy-six patients to be diagnosed with OAML and performed bone marrow biopsy and imaging study at Yeungnam University Hospital in 1995–2014 were enrolled. Patients with symptoms limited to the ocular adnexa were included. Computed tomography, magnetic resonance imaging, positron emission tomography (PET), and bone marrow biopsies were performed for diagnosis, NM staging and follow up evaluation. Most patients were treated with external beam irradiation (median dose, 30 Gray (Gy)). The relapse-free survival (RFS) was analyzed according to the tumor laterality and TNM stage. The median follow-up period was 72 months. The 5-year RFS and overall survival rates were 82.1% and 95.6% respectively. Of all 76 patients, lymph node and bone marrow involvement was identified in 1 patient, respectively. Among the 3 patients with T4 stage as tumor invasion beyond ocular adnexa, bone marrow involvement was confirmed in a patient with left cheek invasion. Only 11 of the 43 patients who underwent PET showed positive uptakes in orbital lesion. The patients with advanced stage were alive without recurrences. Bone marrow examination is useful in OAML patients with T4 for extended stage assessment. The AJCC TNM staging system was not significantly predictive factor for relapse, but may contribute to clarifying the patient group that needs bone marrow study.

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Acknowledgement

We are very grateful to the patients and their families who contributed to this study.

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No funding taken. The authors received no specific funding for this work.

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Authors and Affiliations

  1. Division of Hematology and Oncology, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea

    Sungwoo Park & Gyeong-Won Lee

  2. Department of Hematology-Oncology, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Korea

    Myung Soo Hyun, Kyung Hee Lee, Sung Ae Koh & Min Kyoung Kim

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  1. Sungwoo Park
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  2. Gyeong-Won Lee
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Correspondence to Min Kyoung Kim.

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Ethical Statement

This study was a retrospective study; data of patients was collected from the hospital database, including demographics as well as patient and disease related characteristics (laboratory data, treatment, and outcome). All data analyzed were a part of routine diagnosis and treatment. Diagnosis and treatment of patients were according to national guidelines and practices. Complete anonymity of patients has been maintained. The paper does not involve primary research. For this type of study formal consent is not required.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Park, S., Lee, GW., Hyun, M.S. et al. Is it Worthwhile to Undergo the Extended Stage Assessment in Orbital and Ocular Adnexal MALT Lymphoma with Symptoms Limited to the Ocular Adnexa?. Indian J Hematol Blood Transfus 38, 24–30 (2022). https://doi.org/10.1007/s12288-021-01429-6

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  • DOI: https://doi.org/10.1007/s12288-021-01429-6

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