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Integrating the second near-infrared fluorescence imaging with clinical techniques for multimodal cancer imaging by neodymium-doped gadolinium tungstate nanoparticles

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Abstract

Second near-infrared (NIR-II) fluorescence imaging is a recently emerged technique and is highly useful for accurate diagnosis of cancer. Although a diverse array of fluorescent nanomaterials have been developed to enable NIR-II fluorescence in various situations, they normally fail to unify the clinical techniques, such as computed tomography (CT) and magnetic resonance imaging (MRI). Therefore, exploiting multimodal agents to integrate the newly emerged NIR-II fluorescence and traditional clinical techniques would be of key significance. Here, we report a rational fabrication of neodymium (Nd)-doped gadolinium tungstate nanoparticles (NPs) that are subsequentially decorated with a hydrophilic layer and demonstrate that they can achieve the harmonious integration of NIR-II fluorescence imaging, CT, and MRI. The NIR-II fluorescence emission was activated by an incident light with discrete wavelength ranging from 250 to 810 nm. NIR-II fluorescence-CT-MRI associated trimodal imaging was subsequently demonstrated for breast cancer by an 808 nm laser, along with the estimation of NIR-II fluorescence imaging for cervical cancer. The integration of newly emerged and traditional clinical imaging techniques highlights the huge potential of rare-earth-doped NPs for multimodal imaging of different types of cancer.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (No. 81901885), the Science and Technology Commission of Shanghai Municipality (Nos. 17JC1400700, 18JC1415500, and 1952710400), the Shanghai Education Development Foundation and the Shanghai Municipal Education Commission (No. 16SG54), and the Cultivating Fund of Frontiers Science Center for Transformative Molecules (No. 2019PT02). The authors declare no competing financial interest.

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  1. Xujiang Yu and Aodenggerile contribute equally to this work.

Authors and Affiliations

  1. Joint Research Center for Precision Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus, Southern Medical University Affiliated Fengxian Hospital, Shanghai, 201499, China

    Xujiang Yu & Zhiqiang Yan

  2. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai, 200240, China

    Xujiang Yu,  Aodenggerile & Huibin Qiu

  3. State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China

    Zhao Jiang & Wanwan Li

  4. State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, 325027, China

    Jianliang Shen

  5. Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, China

    Jianliang Shen

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  1. Xujiang Yu
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Integrating the second near-infrared fluorescence imaging with clinical techniques for multimodal cancer imaging by neodymium-doped gadolinium tungstate nanoparticles

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Yu, X., Aodenggerile, Jiang, Z. et al. Integrating the second near-infrared fluorescence imaging with clinical techniques for multimodal cancer imaging by neodymium-doped gadolinium tungstate nanoparticles. Nano Res. 14, 2160–2170 (2021). https://doi.org/10.1007/s12274-020-3136-7

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