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Association Between the Early Serum Lipid Metabolism Profile and Delayed Neurocognitive Recovery After Cardiopulmonary Bypass in Cardiac Surgical Patients: a Pilot Study

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Abstract

Cardiac surgery with extracorporeal circulation is considered to be one of the surgical types with the highest incidence of delayed neurocognitive recovery (DNR), but the mechanism is unclear. Metabolomics technology can be used to understand the early postoperative metabolic profile and find the relationship between serum metabolites and disease. We performed untargeted analyses of postoperative serum metabolites in all surgical groups, as well as serum metabolites in healthy nonsurgical adults, by using liquid chromatography‒mass spectrometry (LC‒MS). DNR after cardiopulmonary bypass surgery occurred in 35% of surgical patients. Sixty-nine metabolites were found to be associated with DNR. Lipids and lipid-like molecules occupy a total of 55 positions. Lipid metabolism occupies an important position in the serum metabolic profile of DNR patients in the early postoperative period. Phosphatidylinositol (PI), sphingomyelin (SM), and phosphatidylglycerol (PG) appear at the highest frequency. Correlation analysis and receiver operator characteristic curve analysis confirmed PI and SM as potential biomarkers for an increased risk of DNR.

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Acknowledgements

The authors thank Oebiotech (Shanghai, China) for technical assistance in the analysis of the metabolomics data.

Funding

This work was supported by the National Natural Science Foundation of China (81901100), Jiangsu Province Special Program for Young Medical Talent (QNRC2016587) to H.H., and Nanjing Introduction Plan of Leading Technology Entrepreneurship Talents (2014B06011) to Y.C.

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  1. He Huang and Jingjing Han contributed equally to this work

Authors and Affiliations

  1. Department of Anesthesiology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Gulou District, Nanjing City, Jiangsu Province, 210029, China

    Jingjing Han, He Huang, Zheng Lei, Rui Pan, Xiaodong Chen, Yu Chen & Ting Lu

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  1. Jingjing Han
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  2. He Huang
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Contributions

Jingjing Han and He Huang analyzed the data and wrote the initial manuscript. Zheng Lei and Rui Pan made the tables and figures. Xiaodong Chen revised the manuscript. Yu Chen and Ting Lu supervised and provided critical comments on the manuscript. All authors have approved the final manuscript.

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Correspondence to Yu Chen or Ting Lu.

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The studies involving human participants were reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Nanjing Medical University.

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The patients/participants provided written informed consent to participate in this study.

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Associate Editor Craig M. Stolen oversaw the review of this article

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Han, J., Huang, H., Lei, Z. et al. Association Between the Early Serum Lipid Metabolism Profile and Delayed Neurocognitive Recovery After Cardiopulmonary Bypass in Cardiac Surgical Patients: a Pilot Study. J. of Cardiovasc. Trans. Res. 16, 662–673 (2023). https://doi.org/10.1007/s12265-022-10332-y

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