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Now We Can Tame the Wild West of Controlling Astrocytes for Treating Neocortical Epilepsy

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References

  1. Patel DC, Tewari BP, Chaunsali L, Sontheimer H. Neuron-glia interactions in the pathophysiology of epilepsy. Nat Rev Neurosci 2019, 20: 282–297.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Devinsky O, Vezzani A, Najjar S, De Lanerolle NC, Rogawski MA. Glia and epilepsy: Excitability and inflammation. Trends Neurosci 2013, 36: 174–184.

    Article  CAS  PubMed  Google Scholar 

  3. Yin YN, Hu J, Wei YL, Li ZL, Luo ZC, Wang RQ. Astrocyte-derived lactate modulates the passive coping response to behavioral challenge in male mice. Neurosci Bull 2021, 37: 1–14.

    Article  CAS  PubMed  Google Scholar 

  4. Zhao J, Sun J, Zheng Y, Zheng Y, Shao Y, Li Y, et al. Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase. Nat Commun 2022, 13: 7136.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Takase KI, Shigeto H, Suzuki SO, Kikuchi H, Ohyagi Y, Kira JI. Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia. Epilepsia 2008, 49: 997–1010.

    Article  PubMed  Google Scholar 

  6. Robel S, Sontheimer H. Glia as drivers of abnormal neuronal activity. Nat Neurosci 2016, 19: 28–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Rose CR, Verkhratsky A. Principles of sodium homeostasis and sodium signalling in astroglia. Glia 2016, 64: 1611–1627.

    Article  PubMed  Google Scholar 

  8. Xu C, Zhang S, Gong Y, Nao J, Shen Y, Tan B, et al. Subicular caspase-1 contributes to pharmacoresistance in temporal lobe epilepsy. Ann Neurol 2021, 90: 377–390.

    Article  CAS  PubMed  Google Scholar 

  9. Ruan Y, Xu C, Lan J, Nao J, Zhang S, Fan F, et al. Low-frequency stimulation at the subiculum is anti-convulsant and anti-drug-resistant in a mouse model of lamotrigine-resistant temporal lobe epilepsy. Neurosci Bull 2020, 36: 654–658.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Liang S, Fan X, Zhao M, Shan X, Li W, Ding P, et al. Clinical practice guidelines for the diagnosis and treatment of adult diffuse glioma-related epilepsy. Cancer Med 2019, 8: 4527–4535.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This Research Highlight was supported by the National Natural Science Foundation of China (82173796).

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Correspondence to Yingying Tang or Cenglin Xu.

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Tang, Y., Zhang, S. & Xu, C. Now We Can Tame the Wild West of Controlling Astrocytes for Treating Neocortical Epilepsy. Neurosci. Bull. 39, 1189–1190 (2023). https://doi.org/10.1007/s12264-023-01048-3

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  • DOI: https://doi.org/10.1007/s12264-023-01048-3

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