Skip to main content

Advertisement

Log in

Visualizing Seizure Propagation in Freely-moving Mice via Miniature Two-photon Microscopy

  • Letter to the Editor
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Muldoon SF, Villette V, Tressard T, Malvache A, Reichinnek S, Bartolomei F. GABAergic inhibition shapes interictal dynamics in awake epileptic mice. Brain 2015, 138: 2875–2890.

    Article  PubMed  Google Scholar 

  2. Wenzel M, Hamm JP, Peterka DS, Yuste R. Reliable and elastic propagation of cortical seizures in vivo. Cell Rep 2017, 19: 2681–2693.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Zong WJ, Wu RL, Li ML, Hu YH, Li YJ, Li JH, et al. Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice. Nat Methods 2017, 14: 713–719.

    Article  CAS  PubMed  Google Scholar 

  4. Chen SY, Wang ZC, Zhang D, Wang AM, Chen LY, Cheng HP, et al. Miniature fluorescence microscopy for imaging brain activity in freely-behaving animals. Neurosci Bull 2020, 36: 1182–1190.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Zong WJ, Wu RL, Chen SY, Wu JJ, Wang HB, Zhao Z, et al. Miniature two-photon microscopy for enlarged field-of-view, multi-plane and long-term brain imaging. Nat Methods 2021, 18: 46–49.

    Article  CAS  PubMed  Google Scholar 

  6. Rancz EA, Moya J, Drawitsch F, Brichta AM, Canals S, Margrie TW. Widespread vestibular activation of the rodent cortex. J Neurosci 2015, 35: 5926–5934.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Szalay G, Martinecz B, Lénárt N, Környei Z, Orsolits B, Judák L, et al. Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. Nat Commun 2016, 7: 11499.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Li Z, You ZY, Li M, Pang L, Cheng J, Wang LC. Protective effect of resveratrol on the brain in a rat model of epilepsy. Neurosci Bull 2017, 33: 273–280.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Cheng A, Gonçalves JT, Golshani P, Arisaka K, Portera-Cailliau C. Simultaneous two-photon calcium imaging at different depths with spatiotemporal multiplexing. Nat Methods 2011, 8: 139–142.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Grienberger C, Konnerth A. Imaging calcium in neurons. Neuron 2012, 73: 862–885.

    Article  CAS  PubMed  Google Scholar 

  11. Minderer M, Harvey CD, Donato F, Moser EI. Neuroscience: Virtual reality explored. Nature 2016, 533: 324–325.

    Article  CAS  PubMed  Google Scholar 

  12. Cui YL, Kataoka Y, Watanabe Y. Role of cortical spreading depression in the pathophysiology of migraine. Neurosci Bull 2014, 30: 812–822.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Dreier JP, Major S, Pannek HW, Woitzik J, Scheel M, Wiesenthal D, et al. Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex. Brain 2012, 135: 259–275.

    Article  PubMed  Google Scholar 

  14. Kramer DR, Fujii T, Ohiorhenuan I, Liu CY. Interplay between cortical spreading depolarization and seizures. Stereotact Funct Neurosurg 2017, 95: 1–5.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We thank Jingruikang Biotechnology Co. (Nanjing, China) for technical support, and Samuel Shi for editorial assistance. This work was supported by the National Natural Science Foundation of China (91642205, 81830038, 91949208, and 82071327) and the Natural Science Foundation of Tianjin Province (18JCYBJC43800).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fu-Dong Shi.

Ethics declarations

Conflicts of interest

The authors declare no competing interests.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (PDF 718 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, Z., Jiang, S., Shi, K. et al. Visualizing Seizure Propagation in Freely-moving Mice via Miniature Two-photon Microscopy. Neurosci. Bull. 38, 1593–1597 (2022). https://doi.org/10.1007/s12264-022-00947-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-022-00947-1

Navigation