References
Portenoy RK, Thaler HT, Kornblith AB, Lepore JM, Friedlander-Klar H, Coyle N. Symptom prevalence, characteristics and distress in a cancer population. Qual Life Res 1994, 3: 183–189.
Meyer N, Paul C, Misery L. Pruritus in cutaneous T-cell lymphomas: Frequent, often severe and difficult to treat. Acta Derm Venereol 2010, 90: 12–17.
Rowe B, Yosipovitch G. Malignancy-associated pruritus. Eur J Pain 2016, 20: 19–23.
Han QJ, Liu D, Convertino M, Wang ZL, Jiang CY, Kim YH, et al. miRNA-711 binds and activates TRPA1 extracellularly to evoke acute and chronic pruritus. Neuron 2018, 99: 449-463.e6.
Wu XS, Sells RE, Hwang ST. Upregulation of inflammatory cytokines and oncogenic signal pathways preceding tumor formation in a murine model of T-cell lymphoma in skin. J Invest Dermatol 2011, 131: 1727–1734.
Maldve RE, Fischer SM. Tumor-promoting activity of 2, 4-dinitrofluorobenzene. Int J Cancer 1995, 60: 545–553.
Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, et al. STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch. Nat Med 2015, 21: 927–931.
Liu T, Han QJ, Chen G, Huang Y, Zhao LX, Berta T, et al. Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice. Pain 2016, 157: 806–817.
Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, et al. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci 2015, 18: 1081–1083.
Chen SS, Zhang JM. Progress in sympathetically mediated pathological pain. J Anesth Perioper Med 2015, 2: 216–225.
McCallum GA, Shiralkar J, Suciu D, Covarrubias G, Yu JS, Karathanasis E, et al. Chronic neural activity recorded within breast tumors. Sci Rep 2020, 10: 14824.
Acknowledgements
This work was supported by the National Natural Science Foundation of China (81971034), The Innovative Research Team of High-level Local Universities in Shanghai, Shanghai Pujiang Program (19PJ1401700), Building Project for Innovative team of National Traditional Chinese Medicine, and The Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, and the Priority Academic Program Development of Jiangsu High Education Institutions (PAPD).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
All authors have no financial interest conflict in this paper.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Tong, F., He, Q., Du, WJ. et al. Sympathetic Nerve Mediated Spinal Glia Activation Underlies Itch in a Cutaneous T-Cell Lymphoma Model. Neurosci. Bull. 38, 435–439 (2022). https://doi.org/10.1007/s12264-021-00805-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12264-021-00805-6